Department of Diagnostic & Interventional Radiology, New Hospitals LTD, 12 Krtsanisi., 0114, Tbilisi, Georgia.
Department of Radiology, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.
Abdom Radiol (NY). 2021 Sep;46(9):4440-4451. doi: 10.1007/s00261-021-03036-5. Epub 2021 Apr 7.
The main purpose of this systematic review was to reflect on recent literature on bariatric LGA embolization for obesity treatment and to compare this new procedure in human and animal studies.
A systematic search of Scopus, MEDLINE, Web of Science, Embase, and Google Scholar was performed to identify human and animal studies employing bariatric LGA embolization to treat obesity. As well, Cochrane's Q test and the I statistic were utilized to determine heterogeneity.
Nine human and four animal studies recruiting a total of 118 cases (n = 78 patients and n = 40 animals) were included in analysis. All assessments on body mass index (BMI), weight, and ghrelin levels had been fulfilled based on before-after (human studies) and intervention-control designs (animal studies) using bariatric LGA embolization. The findings suggested that bariatric LGA embolization had significantly decreased BMI (mean difference (MD): - 2.66, 95% confidence interval [CI] - 3.74, - 1.58, P < 0.001) and weight (MD: - 8.69, 95% CI - 10.48, - 6.89, P < 0.001) in humans. Although overall pooled estimate showed no significant changes in ghrelin levels following this procedure (Hedges' g statistic: - 0.91, 95% CI - 1.83, 0.01, P = 0.05) in humans, a significant reduction was observed in animal studies (MD: - 756.56, 95% CI - 1098.79, - 414.33, P < 0.001) along with a significant drop in weight (MD: - 7.64, 95% CI - 13.73, - 1.54, P < 0.001).
The present study concluded that ghrelin levels in humans had not been affected, although bariatric LGA embolization might significantly improve BMI and weight.
本系统评价的主要目的是回顾近期关于肥胖治疗用减重型胃左动脉栓塞术的文献，并比较人体和动物研究中的这一新方法。
系统检索 Scopus、MEDLINE、Web of Science、Embase 和 Google Scholar，以确定采用减重型胃左动脉栓塞术治疗肥胖的人体和动物研究。同时，利用 Cochrane 的 Q 检验和 I 统计量来确定异质性。
纳入了 9 项人体研究和 4 项动物研究，共纳入 118 例患者（n=78 例患者和 n=40 例动物）。所有评估体重指数（BMI）、体重和 ghrelin 水平的研究均基于人体研究的前后对照设计和动物研究的干预对照设计。研究结果表明，减重型胃左动脉栓塞术显著降低了 BMI（平均差异（MD）：-2.66，95%置信区间[CI]：-3.74，-1.58，P<0.001）和体重（MD：-8.69，95%CI：-10.48，-6.89，P<0.001）。尽管总体合并估计显示，人体研究中该程序后 ghrelin 水平没有显著变化（Hedges'g 统计量：-0.91，95%CI：-1.83，0.01，P=0.05），但动物研究中观察到显著降低（MD：-756.56，95%CI：-1098.79，-414.33，P<0.001），体重也显著下降（MD：-7.64，95%CI：-13.73，-1.54，P<0.001）。
本研究的结论是，尽管减重型胃左动脉栓塞术可能显著改善 BMI 和体重，但人体的 ghrelin 水平没有受到影响。
