Scotti Andrea, Benanti Elisa, Augelli Federica, Baruffaldi Preis Franz Wilhelm
Department of Plastic Surgery, Niguarda Ca' Granda Hospital, Milan, Italy.
Pediatr Neurosurg. 2021;56(3):268-273. doi: 10.1159/000512022. Epub 2021 Apr 7.
Aplasia cutis congenita (ACC) is a rare congenital abnormality characterized by the absence of a portion of skin at birth which most commonly involves the scalp and can affect the galea, the pericranium, the bone, and the dura mater. It can be an isolated condition or associated with other disorders.
We present a case of ACC with a large defect of the scalp and the underlying bone treated with the use of Integra® Dermal regeneration template. At 5 months of follow-up, the wound is completely healed and the bony defect greatly reduced. Contraction of the area of alopecia was observed.
Several surgical and conservative options have been described to treat this congenital condition: advanced dressing, skin graft, local flaps, free flaps, and other methods. In our case, we used Integra® Dermal templates which provide a barrier for infections, promote cellular activity for a rapid vascularization, and improve healing.
先天性皮肤发育不全（ACC）是一种罕见的先天性异常，其特征是出生时部分皮肤缺失，最常见于头皮，可累及帽状腱膜、颅骨膜、骨骼和硬脑膜。它可以是一种孤立的病症，也可与其他疾病相关。
我们报告一例先天性皮肤发育不全患者，头皮及颅骨有大面积缺损，采用Integra®真皮再生模板进行治疗。随访5个月时，伤口完全愈合，骨缺损大幅减少。观察到脱发区域有收缩。
已有多种手术和保守治疗方案用于治疗这种先天性疾病：先进敷料、皮肤移植、局部皮瓣、游离皮瓣及其他方法。在我们的病例中，我们使用了Integra®真皮模板，它为感染提供屏障，促进细胞活性以实现快速血管化，并改善愈合。
