阻塞性睡眠呼吸暂停作为脑出血的一个危险因素。
Obstructive Sleep Apnea as a Risk Factor for Intracerebral Hemorrhage.
机构信息
Department of Pulmonary, Critical Care, and Sleep Medicine (J.H.G., M.A.P., H.K.Y.), Yale University, New Haven, CT.
Department of Neurology (G.J.F., K.N.V., A.C.L., L.H.S., K.N.S.), Yale University, New Haven, CT.
出版信息
Stroke. 2021 May;52(5):1835-1838. doi: 10.1161/STROKEAHA.120.033342. Epub 2021 Apr 8.
BACKGROUND AND PURPOSE
To determine whether obstructive sleep apnea (OSA) is associated with intracerebral hemorrhage (ICH) risk, we assessed premorbid OSA exposure of patients with nontraumatic ICH and matched controls.
METHODS
Ethnic/Racial Variations of Intracerebral Hemorrhage is a multicenter, case-control study evaluating risk factors for ICH that recruited 3000 cases with ICH and 3000 controls. OSA status was ascertained using the Berlin Questionnaire as a surrogate for premorbid OSA. We performed logistic regression analyses to evaluate the association between OSA and ICH.
RESULTS
Two thousand and sixty-four (71%) cases and 1516 (52%) controls were classified as having OSA by the Berlin Questionnaire. Cases with OSA were significantly more likely to be male and have hypertension, heart disease, hyperlipidemia, and higher body mass index compared with those without OSA. OSA was more common among cases compared with controls (71% versus 52%, odds ratio, 2.28 [95% CI, 2.05-2.55]). In a multivariable logistic regression model, OSA was associated with increased risk for ICH (odds ratio, 1.47 [95% CI, 1.29-1.67]).
CONCLUSIONS
OSA is a risk factor for ICH.
背景与目的
为了确定阻塞性睡眠呼吸暂停（OSA）是否与颅内出血（ICH）风险相关，我们评估了非创伤性 ICH 患者和匹配对照者的病前 OSA 暴露情况。
方法
颅内出血的种族/民族差异是一项多中心病例对照研究，评估了 ICH 的危险因素，共纳入了 3000 例 ICH 患者和 3000 例对照者。使用柏林问卷作为病前 OSA 的替代指标来确定 OSA 状态。我们进行了逻辑回归分析，以评估 OSA 与 ICH 之间的关联。
结果
2064 例（71%）病例和 1516 例（52%）对照者通过柏林问卷被归类为 OSA。与无 OSA 者相比，OSA 者更可能为男性，且患有高血压、心脏病、高脂血症和更高的体重指数。与对照者相比，病例者中 OSA 更为常见（71%比 52%，比值比，2.28[95%置信区间，2.05-2.55]）。在多变量逻辑回归模型中，OSA 与 ICH 风险增加相关（比值比，1.47[95%置信区间，1.29-1.67]）。
结论
OSA 是 ICH 的一个危险因素。
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