Bach Institute of Biochemistry, Federal Research Centre "Fundamentals of Biotechnology", Russian Academy of Sciences, Moscow, 119071, Russia.
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
Biochemistry (Mosc). 2021 Jan;86(Suppl 1):S109-S119. doi: 10.1134/S000629792114008X.
Mycobacterium tuberculosis possesses a significant arsenal of strategies to combat immune defense of the host organism. Small noncoding RNAs, which constitute the largest group of regulatory RNAs, play an important role in the host-pathogen interactions and represent one of the levels of the regulation of interactions of microbial cells with their environment. The regulatory role of small RNAs in pathogenic bacteria is essential when rapid adaptation to the changing environmental conditions with further synchronization of metabolic reactions are required to ensure microbial survival and infection progression. During the past few years, eight small RNAs from M. tuberculosis have been functionally characterized, and targets for four of them have been identified. Small RNAs from M. tuberculosis and other pathogenic microorganisms were found to be one of the most important functional factors in the adaptive response to changing environmental conditions.
结核分枝杆菌拥有一系列重要的策略来对抗宿主的免疫防御。小非编码 RNA 是最大的一类调控 RNA，它们在宿主-病原体相互作用中发挥着重要作用，代表了微生物细胞与环境相互作用调控的一个层面。当需要快速适应环境条件的变化，并进一步同步代谢反应以确保微生物的生存和感染进展时，小 RNA 在致病性细菌中的调节作用是必不可少的。在过去的几年中，已经对结核分枝杆菌的 8 种小 RNA 进行了功能表征，其中 4 种的靶标已经被确定。来自结核分枝杆菌和其他病原微生物的小 RNA 被发现是适应环境变化的重要功能因素之一。
