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[急性酒精中毒大鼠骨骼肌的病变]

[Lesions of skeletal muscles in rats with acute alcoholic intoxication].

作者信息

Britvan I Ia

出版信息

Biull Eksp Biol Med. 1988 May;105(5):606-8.

PMID:3382741
Abstract

Histological and histochemical studies of the rat skeletal muscles in acute alcohol intoxication have revealed metabolic disturbances, characterized by a decreased glycogen level, small-drop fatty infiltration, decreased activity of aerobic and enhanced activity of anaerobic enzyme glycolysis, dystrophic and focal necrotic myocyte changes. Acute alcohol intoxication in fasting animals is accompanied by more pronounced dystrophic and necrotic myocyte changes, decreased glycogen and lipid content.

摘要

对急性酒精中毒大鼠骨骼肌的组织学和组织化学研究揭示了代谢紊乱,其特征为糖原水平降低、小滴状脂肪浸润、有氧酶活性降低和无氧酶糖酵解活性增强、营养不良性和局灶性坏死性肌细胞变化。禁食动物的急性酒精中毒伴有更明显的营养不良性和坏死性肌细胞变化、糖原和脂质含量降低。

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