Iakovleva L M, Lobovtseva L A
Morfologiia. 2012;141(1):62-6.
The effect of chronic alcohol intoxication of 2, 4 and 6 months' duration on the morpho-functional state of the ileum was studied in male rats (n = 36) using histological, morphometric and histochemical methods. The results show that alcohol intoxication for a period of 2 months induced the changes in the mucous membrane of the ileum which in the form of its hypertrophy accompanied by the increase of epitheliocyte mitotic activity and goblet cell number. The activity of succinate dehydrogenase in the enterocytes and muscular tunic myocytes of the ileum wall was increased. After 4 and 6 months the changes included the inhibition of enterocyte mitotic activity. By 6 months of the experiment marked atrophy of the mucous membrane was noted. Succinate dehydrogenase activity was decreased in all the structures studied.
采用组织学、形态计量学和组织化学方法，对36只雄性大鼠进行了为期2、4和6个月的慢性酒精中毒实验，研究其对回肠形态功能状态的影响。结果表明，2个月的酒精中毒可引起回肠黏膜改变，表现为黏膜肥大，伴有上皮细胞有丝分裂活性和杯状细胞数量增加。回肠壁肠上皮细胞和肌层肌细胞中的琥珀酸脱氢酶活性增强。4个月和6个月后，变化包括肠上皮细胞有丝分裂活性受到抑制。到实验6个月时，可见黏膜明显萎缩。在所研究的所有结构中，琥珀酸脱氢酶活性均降低。
