Smyth C M, Benn D E, Reeve T S
Department of Surgery, University of Sydney, Royal North Shore Hospital, St. Leonards N.S.W., Australia.
Breast Cancer Res Treat. 1988 Apr;11(1):45-50. doi: 10.1007/BF01807557.
There is controversy in the literature regarding the effects of endogenous hormones on estrogen receptors (ER) and progesterone receptors (PR) in young women with breast cancer. We studied 117 young women with primary breast cancer and assessed their breast biopsies for ER and PR. The women had a record of their last menstrual period prior to breast biopsy. The menstrual cycle was divided into four phases--early proliferative (days 1-7), late proliferative (days 8-15), early secretory (days 16-22), and late secretory (days 23-30). There were lower levels of both ER and PR in biopsies excised during the early secretory phase than in other phases of the cycle; early proliferative phase receptor positive medians of ER = 77 fmol/mg protein and PR = 467 fmol/mg protein fell to ER = 28 fmol/mg and PR = 128 fmol/mg protein in the early secretory phase.
关于内源性激素对年轻乳腺癌女性雌激素受体（ER）和孕激素受体（PR）的影响，文献中存在争议。我们研究了117名原发性乳腺癌年轻女性，并对她们的乳腺活检组织进行了ER和PR评估。这些女性在乳腺活检前有末次月经记录。月经周期分为四个阶段——增殖早期（第1 - 7天）、增殖晚期（第8 - 15天）、分泌早期（第16 - 22天）和分泌晚期（第23 - 30天）。与月经周期的其他阶段相比，在分泌早期切除的活检组织中ER和PR水平均较低；增殖早期受体阳性中位数ER = 77 fmol/mg蛋白、PR = 467 fmol/mg蛋白，在分泌早期降至ER = 28 fmol/mg、PR = 128 fmol/mg蛋白。
