Mohemmad Rizal Mohemmad Redzuan, Hayat Khan Amer, Noor Harun Sabariah, Saleh Zaiton
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Health District Pontian, Ministry of Health, Johor, Malaysia.
J Pharm Bioallied Sci. 2020 Nov;12(Suppl 2):S657-S662. doi: 10.4103/jpbs.JPBS_253_19. Epub 2020 Nov 5.
The objective of this study was to review the significant differences of MMT outcomes related to drug use behavior, health status, and social behavioral functioning between genders.
A search of publication was conducted in PubMed/MEDLINE, Embase, CINAHL, PsycINFO, and Scopus database. Two reviewers independently screened the titles, abstracts, and keyword use for the search. Inclusion of studies was based on randomized controlled trials (RCTs) or observational studies that report the difference of opioid addiction treatment outcomes between genders. Any conflict between the two reviewers was resolved through discussion and consensus. The systematic review followed the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines and was registered in PROSPERO with a registration number CRD42019116261.
A total of 25 studies were evaluated as part of qualitative synthesis. The review resulted in three main themes, which are (1) improving well-being and methadone-related outcome (five subthemes), (2) impact on social and behavioral (four subthemes), and (3) illicit drug use pattern-related behavior (four subthemes).
This review will highlight how men and women differ in methadone treatment outcomes for further application and improvement in the clinical setting.
本研究的目的是回顾性别之间与药物使用行为、健康状况和社会行为功能相关的MMT结果的显著差异。
在PubMed/MEDLINE、Embase、CINAHL、PsycINFO和Scopus数据库中进行文献检索。两名评审员独立筛选检索的标题、摘要和关键词使用情况。纳入的研究基于报告性别之间阿片类药物成瘾治疗结果差异的随机对照试验（RCT）或观察性研究。两名评审员之间的任何冲突都通过讨论和达成共识来解决。系统评价遵循系统评价和Meta分析的首选报告项目（PRISMA）指南，并在PROSPERO中注册，注册号为CRD42019116261。
共有25项研究被评估为定性综合的一部分。该综述产生了三个主要主题，即（1）改善幸福感和与美沙酮相关的结果（五个子主题），（2）对社会和行为的影响（四个子主题），以及（3）与非法药物使用模式相关的行为（四个子主题）。
本综述将突出男性和女性在美沙酮治疗结果方面的差异，以便在临床环境中进一步应用和改进。
