海兔静止神经元中一种钙激活的非选择性阳离子电导。

A calcium-activated, nonselective cationic conductance in Aplysia silent neurons.

作者信息

Jones L S, Lewis D V

机构信息

Department of Pediatrics (Neurology), Duke University Medical Center, Durham, NC 27710.

出版信息

Brain Res Bull. 1988 May;20(5):607-9. doi: 10.1016/0361-9230(88)90220-1.

DOI:10.1016/0361-9230(88)90220-1

PMID:3382966

Abstract

We have previously reported the activation of a triphasic current response by calcium injection in voltage-clamped, nonbursting neurons of Aplysia californica. Present evidence indicates that the second phase, a delayed inward current that peaks 10-20 seconds after the end of the injection, is a calcium-activated, nonselective cationic conductance. It can be carried by both sodium and calcium, is not sensitive to chloride concentration changes, but is voltage sensitive, decreasing in amplitude with hyperpolarization.

摘要

我们之前报道过，在加州海兔电压钳制的非爆发性神经元中，通过注入钙可激活一种三相电流反应。目前的证据表明，第二相，即注入结束后10 - 20秒达到峰值的延迟内向电流，是一种钙激活的非选择性阳离子电导。它可由钠和钙携带，对氯离子浓度变化不敏感，但对电压敏感，其幅度随超极化而降低。