Calne D B, Lees A J
Belzberg Laboratory of Clinical Neuroscience, University of British Columbia, Vancouver, Canada.
Can J Neurol Sci. 1988 May;15(2):135-8. doi: 10.1017/s0317167100027499.
We have studied 11 patients with neurological deficits due to the pandemic of encephalitis lethargica, all of whom had remained in hospital for more than forty years. Retrospective information obtained from physicians and nurses dating back as far as 1931, our own Webster and Northwestern University Disability Rating Scales available from 1976, photographic records, published narrative and hospital charts all indicate that neurological disabilities attributable to basal ganglia damage frequently increase in late life. Deterioration was most marked in motor function and largely spared the intellect, special senses and somatosensory system. The findings are discussed in relation to current hypotheses concerning the aetiology of Parkinson's disease.
我们研究了11例因昏睡性脑炎大流行而出现神经功能缺损的患者，他们都已住院超过40年。从可追溯到1931年的医生和护士那里获得的回顾性信息、我们自己从1976年开始使用的韦伯斯特和西北大学残疾评定量表、照片记录、已发表的叙述以及医院病历均表明，基底神经节损伤所致的神经功能残疾在晚年常常加重。运动功能恶化最为明显，而智力、特殊感觉和躯体感觉系统在很大程度上未受影响。我们结合当前关于帕金森病病因的假说对这些发现进行了讨论。
