Vieregge P, Reinhardt V, Höft B
Klinik für Neurologie, Medizinische Universität zu Lübeck, Federal Republic of Germany.
J Neurol. 1991 Aug;238(5):299-303. doi: 10.1007/BF00319743.
Follow-up data are presented of ten patients with autopsy-proven postencephalitic Parkinson's syndrome (PEP) (mean age at death: 56.0 years) with regard to motor and psychic deterioration over a period of institutional observation between 3 and 30 years. Four patients showed deterioration of their Hoehn-Yahr score of at least one grade. These patients did not differ statistically with respect to age of occurrence of lethargic encephalitis, interval to PEP, age at start of PEP, duration of survival with PEP, and age at death. Motor deterioration in these patients seems to be attributed more to inherent disease progression, rather than to an age-related process. Clinical and pathological evidence for this conclusion is presented.
本文呈现了10例经尸检证实的脑炎后帕金森综合征（PEP）患者（死亡时平均年龄：56.0岁）在3至30年机构观察期内运动和精神衰退方面的随访数据。4例患者的霍恩-亚尔分级至少恶化了一级。这些患者在昏睡性脑炎发病年龄、至PEP的间隔时间、PEP开始时的年龄、PEP存活时间以及死亡年龄方面无统计学差异。这些患者的运动衰退似乎更多归因于疾病的内在进展，而非与年龄相关的过程。本文提供了支持该结论的临床和病理证据。
