Taxy J B, Battifora H
Division of Pathology, Lutheran General Hospital, Park Ridge, Illinois 60068.
Cancer. 1988 Jul 1;62(1):210-6. doi: 10.1002/1097-0142(19880701)62:1<210::aid-cncr2820620132>3.0.co;2-8.
Three cases of angiosarcoma in the stomach, small bowel, and colon, respectively, are reported. The gastric lesion occurred many years after historic evidence of cutaneous Kaposi's sarcoma. Two of the three lesions exhibited multifocality, and all demonstrated aggressive biologic courses. The varied histologic features of angiosarcoma make this diagnosis difficult to establish in an unusual location such as the gastrointestinal tract. The use of immunohistochemistry for a panel of antibodies, particularly the successful reaction with Factor VIII-related antigen, is important in evaluating light microscopically unusual tumors. A delicate framework of collagen type IV was elicited in each case, but ultrastructurally correlated with short segments of basal lamina in one case. This suggests that the absence of the traditional morphologic expression of basal lamina does not preclude its presence and emphasizes the sensitivity of immunohistochemistry. The lack of previously reported cases of gastrointestinal angiosarcoma may be because the tumor is underrecognized or because it is truly a rare occurrence.
分别报告了3例胃、小肠和结肠血管肉瘤病例。胃部病变发生在有皮肤卡波西肉瘤病史多年之后。3个病变中有2个表现为多灶性，且均显示出侵袭性生物学行为。血管肉瘤多样的组织学特征使得在胃肠道等不寻常部位难以确诊。使用一组抗体进行免疫组织化学检测，特别是与VIII因子相关抗原的成功反应，对于评估光镜下不寻常的肿瘤很重要。在每个病例中均引出了IV型胶原的精细框架，但超微结构上仅在1例中与短段基底膜相关。这表明缺乏基底膜的传统形态学表现并不排除其存在，并强调了免疫组织化学的敏感性。此前未报告胃肠道血管肉瘤病例，可能是因为该肿瘤未得到充分认识，或者确实是罕见病例。
