Jakubowski A A, Kemeny N
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Cancer. 1988 Jul 15;62(2):266-9. doi: 10.1002/1097-0142(19880715)62:2<266::aid-cncr2820620207>3.0.co;2-y.
Cardiac symptoms, including hypotension, developed in three patients with advanced colorectal carcinoma while being treated with cisplatin (CDDP) and 5-fluorouracil (5-FU). In two patients, hypotension was associated with severe left ventricular dysfunction. All three patients required therapy discontinuation. Cardiac enzymes remained normal despite transient electrocardiographic (EKG) changes. The presentation and cardiac evaluation (hemodynamic, echocardiographic, and scintigraphic) of these patients suggest new manifestations of 5-FU cardiotoxicity that may be influenced by CDDP. The possible pathophysiologic mechanisms are discussed.
三名晚期结直肠癌患者在接受顺铂（CDDP）和5-氟尿嘧啶（5-FU）治疗时出现了包括低血压在内的心脏症状。两名患者的低血压与严重左心室功能障碍有关。所有三名患者都需要停止治疗。尽管心电图（EKG）有短暂变化，但心肌酶仍保持正常。这些患者的临床表现和心脏评估（血流动力学、超声心动图和闪烁扫描）提示5-FU心脏毒性可能有新的表现形式，且可能受CDDP影响。文中讨论了可能的病理生理机制。
