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肾脏损伤和疾病中的上皮细胞增殖和细胞周期失调。

Epithelial proliferation and cell cycle dysregulation in kidney injury and disease.

机构信息

Department of Medicine, Nephrology Division, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Department of Medicine, Nephrology Division, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

出版信息

Kidney Int. 2021 Jul;100(1):67-78. doi: 10.1016/j.kint.2021.03.024. Epub 2021 Apr 6.

Abstract

Various cellular insults and injury to renal epithelial cells stimulate repair mechanisms to adapt and restore the organ homeostasis. Renal tubular epithelial cells are endowed with regenerative capacity, which allows for a restoration of nephron function after acute kidney injury. However, recent evidence indicates that the repair is often incomplete, leading to maladaptive responses that promote the progression to chronic kidney disease. The dysregulated cell cycle and proliferation is also a key feature of renal tubular epithelial cells in polycystic kidney disease and HIV-associated nephropathy. Therefore, in this review, we provide an overview of cell cycle regulation and the consequences of dysregulated cell proliferation in acute kidney injury, polycystic kidney disease, and HIV-associated nephropathy. An increased understanding of these processes may help define better targets for kidney repair and combat chronic kidney disease progression.

摘要

各种细胞损伤和肾上皮细胞损伤会刺激修复机制以适应和恢复器官的稳态。肾小管上皮细胞具有再生能力,这使得急性肾损伤后可以恢复肾单位的功能。然而,最近的证据表明,修复往往是不完全的,导致适应性反应,从而促进慢性肾脏病的进展。细胞周期紊乱和增殖也是多囊肾病和 HIV 相关性肾病中肾小管上皮细胞的一个关键特征。因此,在这篇综述中,我们概述了细胞周期调控以及细胞增殖失调在急性肾损伤、多囊肾病和 HIV 相关性肾病中的后果。深入了解这些过程可能有助于确定更好的肾脏修复靶点,以对抗慢性肾脏病的进展。

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