内源性和外源性成纤维细胞生长因子 1 在心血管系统及相关疾病中的调节作用。
Regulatory role of endogenous and exogenous fibroblast growth factor 1 in the cardiovascular system and related diseases.
机构信息
School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China.
出版信息
Pharmacol Res. 2021 Jul;169:105596. doi: 10.1016/j.phrs.2021.105596. Epub 2021 Apr 5.
Fibroblast growth factor 1 (FGF1) has a critical regulatory role in the development of the cardiovascular system (CVS) and is strongly associated with the progression or treatment of cardiovascular diseases (CVDs). However, the regulatory mechanisms of FGF1 in CVS and CVDs have not yet been fully elucidated. Therefore, this review article summarized the existing literature reports on the role of FGF1 in CVS under physiological and pathological conditions. First, the expression and physiological functions of endogenous FGF1 is fully demonstrated. Then, we analyzed the role of exogenous FGF1 in normal CVS and related pathological processes. Specifically, the potential signaling pathways might be mediated by FGF1 in CVDs treatment is discussed in detail. In addition, the barriers and feasible solutions for the application of FGF1 are further analyzed. Finally, we highlight therapeutic considerations of FGF1 for CVDs in the future. Thus, this article may be as a reference to provide some ideas for the follow-up research.
成纤维细胞生长因子 1（FGF1）在心血管系统（CVS）的发育中具有关键的调节作用，与心血管疾病（CVDs）的进展或治疗密切相关。然而，FGF1 在 CVS 和 CVDs 中的调节机制尚未完全阐明。因此，本文综述了现有文献中关于 FGF1 在生理和病理条件下对 CVS 的作用的报道。首先，充分证明了内源性 FGF1 的表达和生理功能。然后，我们分析了外源性 FGF1 在正常 CVS 和相关病理过程中的作用。具体来说，详细讨论了 FGF1 在 CVDs 治疗中可能介导的潜在信号通路。此外，还进一步分析了 FGF1 应用的障碍和可行的解决方案。最后，我们强调了 FGF1 对未来 CVDs 的治疗考虑。因此，本文可能为后续研究提供一些参考思路。
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