State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, No. 1166, Liutai Avenue, Chengdu 611137, PR China.
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, PR China.
Pharmacol Res. 2021 Jul;169:105627. doi: 10.1016/j.phrs.2021.105627. Epub 2021 Apr 21.
With the coming acceleration of global population aging, the incidence rate of cardio-cerebrovascular diseases (CVDs) is increasing. It has become the leading cause of human mortality. As a natural drug, borneol (BO) not only has anti-inflammatory, anti-oxidant, anti-apoptotic, anti-coagulant activities and improves energy metabolism but can also promote drugs to enter the target organs or tissues through various physiological barriers, such as the blood-brain barrier (BBB), mucous membrane, skin. Thus, it has a significant therapeutic effect on various CVDs, which has been confirmed in a large number of studies. However, the pharmacological actions and mechanisms of BO on CVDs have not been fully investigated. Hence, this review summarizes the pharmacological actions and possible mechanisms of BO, which provides novel ideas for the treatment of CVDs.
随着全球人口老龄化的加速，心脑血管疾病（CVDs）的发病率正在上升。它已成为人类死亡的主要原因。作为一种天然药物，冰片（BO）不仅具有抗炎、抗氧化、抗凋亡、抗凝血作用，可改善能量代谢，还可以通过各种生理屏障（如血脑屏障[BBB]、黏膜、皮肤）促进药物进入靶器官或组织。因此，它对各种 CVDs 具有显著的治疗作用，这已在大量研究中得到证实。然而，BO 对 CVDs 的药理作用和机制尚未得到充分研究。因此，本综述总结了 BO 的药理作用及其可能的机制，为 CVDs 的治疗提供了新的思路。
