Vik-Mo H, Rosland G A, Følling M, Danielsen R
Haukeland Hospital, University of Bergen, Norway.
Cathet Cardiovasc Diagn. 1988;14(3):143-9. doi: 10.1002/ccd.1810140302.
The cardiovascular effects of two nonionic contrast agents with low osmolality (iohexol and metrizamide) were compared with one standard ionic, high-osmolality contrast agent (metrizoate) used for left ventricular (LV) angiography in patients with coronary heart disease. Metrizoate induced a marked elevation of LV end-diastolic pressure and LV systolic pressure and an increase in cardiac output after a delay of a few minutes. All these changes were significantly less severe with iohexol and metrizamide. Hypotension occurring 30 sec after LV angiography was observed only with use of metrizoate. All agents increased heart rate, but the increase after metrizoate was significantly more pronounced and prolonged. The PQ and QT interval was prolonged only by metrizoate. The subjective symptoms were significantly more marked with metrizoate than with the two other agents. Thus the new nonionic contrast agent iohexol and metrizamide produced markedly less hemodynamic and electrocardiographic disturbance than the ionic agent metrizoate.
将两种低渗非离子型造影剂（碘海醇和甲泛葡胺）的心血管效应与一种用于冠心病患者左心室（LV）血管造影的标准离子型高渗造影剂（泛影葡胺）进行了比较。泛影葡胺使左心室舒张末期压力和左心室收缩压显著升高，并在几分钟延迟后使心输出量增加。碘海醇和甲泛葡胺引起的所有这些变化明显较轻。仅在使用泛影葡胺时观察到左心室血管造影后30秒出现低血压。所有药物均使心率增加，但泛影葡胺后的增加明显更显著且持续时间更长。PQ和QT间期仅由泛影葡胺延长。泛影葡胺引起的主观症状比其他两种药物明显更明显。因此，新型非离子型造影剂碘海醇和甲泛葡胺产生的血流动力学和心电图干扰明显少于离子型造影剂泛影葡胺。
