Division of Cancer Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, St Mary's Hospital, Research Floor, Oxford Road, Manchester, M13 9WL, UK.
Department of Obstetrics and Gynaecology, Manchester Academic Health Science Centre, St Mary's Hospital, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Level 5, Research, Oxford Road, Manchester, UK.
BMC Cancer. 2021 Apr 8;21(1):378. doi: 10.1186/s12885-021-08019-9.
Despite improvements in median survival some patients with advanced ovarian cancer die within 100 days of diagnosis; the reasons for which remain poorly understood. Here we investigate if ultra short-term survival can be explained by patient characteristics or treatment pathways.
A nested case comparison study was used to examine differences between patients with high grade serous ovarian/fallopian tube cancer who died within 100 days (n = 28) compared to a comparison group of patients matched for histology and including any survival greater than 100 days (n = 134).
Cases and comparison patients had similar ages, BMI, ACE-27, deprivation indices, and distribution of disease on CT. There were no significant delays in time to diagnosis or treatment (p = 0.68) between the groups. However, cases had lower serum albumin, haemoglobin and higher platelet counts than matched comparison patients (p < 0.0001) and a worse performance score (P = 0.006).
Patients who die rapidly after a diagnosis of ovarian cancer are only slightly older and have similar pre treatment frailty compared to patients whose survival approaches the median. However they do appear to undergo greater physiological compromise as a result of their disease.
尽管中位生存时间有所改善，但仍有一些晚期卵巢癌患者在诊断后 100 天内死亡；其原因仍知之甚少。在此，我们研究了超短期存活是否可以通过患者特征或治疗途径来解释。
采用嵌套病例对照研究，比较了在 100 天内死亡的高级别浆液性卵巢/输卵管癌患者（n=28）与按组织学匹配且生存时间超过 100 天的对照组患者（n=134）之间的差异。
病例组和对照组患者的年龄、BMI、ACE-27、贫困指数和 CT 上疾病分布相似。两组之间在诊断和治疗时间上没有明显延迟（p=0.68）。然而，病例组的血清白蛋白、血红蛋白水平较低，血小板计数较高（p<0.0001），且表现评分较差（p=0.006）。
与生存接近中位的患者相比，诊断为卵巢癌后迅速死亡的患者仅略年长，且治疗前虚弱程度相似。然而，他们的疾病似乎导致了更大的生理恶化。
