Department of Psychiatry, University of Ibadan, Ibadan, Nigeria.
Department of Psychiatry, College of Health Sciences, University of Abuja, Nigeria.
Encephale. 2021 Oct;47(5):401-405. doi: 10.1016/j.encep.2020.12.004. Epub 2021 Apr 5.
Despite the ubiquity of sleep disturbance in schizophrenia, it has generally been overlooked as a potential contributor to cognitive impairments. The main aim of this study was to find out if impaired sleep quality contributes to cognitive impairments in patients with a diagnosis of schizophrenia who are in remission.
The study was conducted at the University College Hospital, Ibadan and State Hospital, Ibadan, Nigeria. The Pittsburgh Sleep Quality Index (PSQI) and Screen for Cognitive Impairment in Psychiatry (SCIP) were applied in this cross-sectional study, to all consecutive and consenting remitted outpatients with schizophrenia (N=130). Other instruments such as Hamilton Depression Rating Scale (HDRS), the Positive and Negative Syndrome Scale (PANSS), sociodemographic and clinical measures were also applied.
There were 130 participants made up of 69 females (53.1%) and 61males(46.9%). The mean age of the participants was 38.5±9.1 years. The prevalence of poor sleep quality in remitted patients with schizophrenia was 56.9%. Sleep quality was significantly negatively correlated with Verbal Learning Test-Immediate (VLT-I) (r(128)=-.18, P=.044) and Verbal Learning Test-Delayed (VLT-D) (r(128)=-.18, P=.037). The variables that independently predicted cognitive functioning were the VLT-I, odds ratio (OR) 0.66; 95% confidence interval ((CI) 0.49-0.88) and education (OR) 0.61;(CI) 0.40- 0.92).
Poor subjective sleep quality measured by the PSQI is linked to cognitive impairment in remitted patients with schizophrenia. We suggest that sleep quality in remitted patients with a diagnosis of schizophrenia should receive better attention by physicians.
尽管精神分裂症患者普遍存在睡眠障碍，但它通常被忽视，认为它是导致认知障碍的潜在因素。本研究的主要目的是探讨睡眠质量受损是否会导致缓解期精神分裂症患者的认知障碍。
该研究在尼日利亚伊巴丹大学教学医院和伊巴丹州立医院进行。本横断面研究采用匹兹堡睡眠质量指数（PSQI）和精神科认知障碍筛查工具（SCIP）对所有连续且同意的缓解期精神分裂症门诊患者（共 130 名）进行了评估。还应用了汉密尔顿抑郁评定量表（HDRS）、阳性和阴性症状量表（PANSS）、社会人口学和临床评估量表等其他工具。
共有 130 名参与者，其中女性 69 名（53.1%），男性 61 名（46.9%）。参与者的平均年龄为 38.5±9.1 岁。缓解期精神分裂症患者中睡眠质量差的患病率为 56.9%。睡眠质量与词语学习测试即时（VLT-I）（r(128)=-.18，P=.044）和词语学习测试延迟（VLT-D）（r(128)=-.18，P=.037）呈显著负相关。独立预测认知功能的变量是 VLT-I，优势比（OR）为 0.66；95%置信区间（CI）为 0.49-0.88）和教育程度（OR）为 0.61；（CI）为 0.40-0.92）。
PSQI 测量的主观睡眠质量差与缓解期精神分裂症患者的认知障碍有关。我们建议，应引起医生对缓解期精神分裂症患者睡眠质量的关注。
