Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing 100096, China.
Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing 100096, China.
Psychiatry Res. 2021 May;299:113849. doi: 10.1016/j.psychres.2021.113849. Epub 2021 Mar 2.
This study aims to elucidate the association paths between subjective sleep quality and the learning and memory ability of drug-free patients with schizophrenia.
150 patients with schizophrenia were recruited. Information on clinical and socio-demographic was obtained, and a neurocognitive battery was administered. The Pittsburgh Sleep Quality Index (PSQI) was used to assess the quality of subjective sleep. The Verbal Learning Test and the Visual Learning Test that were taken from the MATRICS Consensus Cognitive Battery were used to assess the patient's ability to learn and recall. Structural equation modelling (SEM) was performed to examine the relationship between subjective sleep quality and learning and memory ability .The model was further modified and fitted.
There were significant negative correlations between learning and memory variables and the PSQI scores or the PANSS scores. Significant direct effect of PSQI on Verbal Learning and Visual Learning, and significant indirect effect of PSQI on Verbal Learning and Visual Learning through psychotic symptoms were found in the most plausible SEM model that explains the data.
Subjective sleep quality has a direct impact on the ability to learn and memory, and indirectly affects the ability to learn and memory through psychotic symptoms in drug-free patients with schizophrenia. Sleep quality could be an intervention target for improving cognitive function in patients with schizophrenia.
本研究旨在阐明精神分裂症非药物治疗患者主观睡眠质量与学习记忆能力之间的关联路径。
招募了 150 名精神分裂症患者。获取了临床和社会人口统计学信息，并进行了神经认知测试。使用匹兹堡睡眠质量指数（PSQI）评估主观睡眠质量。采用取自 MATRICS 共识认知测试包的词语学习测试和视觉学习测试评估患者的学习和回忆能力。采用结构方程模型（SEM）检验主观睡眠质量与学习记忆能力之间的关系。进一步对模型进行修正和拟合。
在最合理的解释数据的 SEM 模型中，学习和记忆变量与 PSQI 评分或 PANSS 评分之间存在显著的负相关。PSQI 对词语学习和视觉学习有显著的直接影响，PSQI 通过精神病症状对词语学习和视觉学习有显著的间接影响。
在精神分裂症非药物治疗患者中，主观睡眠质量对学习和记忆能力有直接影响，通过精神病症状对学习和记忆能力有间接影响。睡眠质量可能是改善精神分裂症患者认知功能的干预靶点。
