Zemet Roni, Orvieto Raoul, Watad Hadel, Barzilay Eran, Zilberberg Eran, Lebovitz Oshrit, Mazaki-Tovi Shali, Haas Jigal
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Tel-Hashomer, Ramat-Gan 52621, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Tel-Hashomer, Ramat-Gan 52621, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Reprod Biomed Online. 2021 May;42(5):930-937. doi: 10.1016/j.rbmo.2021.01.013. Epub 2021 Jan 28.
Is physical activity after embryo transfer, as assessed by a smart band activity tracker, associated with decreased pregnancy rates?
Prospective observational cohort study comprising infertile women aged < 38 years, who had undergone fewer than three previous embryo transfers, achieved a good ovarian response and were undergoing frozen-thawed embryo transfer in a tertiary-referral centre. A validated smart band activity tracker was used to assess physical activity level immediately after the embryo transfer and until the pregnancy test. No specific recommendations were given to participants on level or intensity of physical activity. Physicians and patients were blinded to the data stored in the pedometer. Primary outcome was ongoing pregnancy rate.
Fifty women met the inclusion criteria. Ongoing pregnancy rate was 30%. In a pooled analysis, participants walked significantly fewer steps per day on the day of embryo transfer compared with the first 2 days after embryo transfer (4075, interquatile range [IQR] 2932-5592 versus 5204, IQR4203-8584, P = 0.01). No significant difference was observed between pregnant women and non-pregnant women in the median steps per day after embryo transfer until serum beta-HCG was measured (7569, IQR 6008-10884 versus 6572.5, IQR 5299-8786, P = 0.43). No significant difference was observed in the median number of steps on the day of embryo transfer or the first 2 days after embryo transfer between pregnant and non-pregnant women.
A quantitative objective assessment of the association between physical activity and pregnancy rates after frozen-thawed embryo transfer was conducted. Ambulation after embryo transfer has no adverse effect on pregnancy rates and, therefore, women should resume regular activity immediately after embryo transfer.
通过智能手环活动追踪器评估，胚胎移植后的身体活动是否与妊娠率降低有关？
前瞻性观察队列研究，纳入年龄小于38岁、既往胚胎移植次数少于3次、卵巢反应良好且在三级转诊中心接受冻融胚胎移植的不孕女性。使用经过验证的智能手环活动追踪器评估胚胎移植后直至妊娠试验期间的身体活动水平。未就身体活动的水平或强度向参与者提供具体建议。医生和患者对计步器中存储的数据不知情。主要结局为持续妊娠率。
50名女性符合纳入标准。持续妊娠率为30%。在汇总分析中，与胚胎移植后的前两天相比，参与者在胚胎移植当天每天行走的步数明显减少（4075步，四分位间距[IQR]2932 - 5592步，而前两天为5204步，IQR4203 - 8584步，P = 0.01）。在测量血清β - HCG之前，妊娠女性和未妊娠女性在胚胎移植后每天的步数中位数之间未观察到显著差异（7569步，IQR 6008 - 10884步，而未妊娠女性为6572.5步，IQR 5299 - 8786步，P = 0.43）。妊娠女性和未妊娠女性在胚胎移植当天或胚胎移植后前两天的步数中位数无显著差异。
对冻融胚胎移植后身体活动与妊娠率之间的关联进行了定量客观评估。胚胎移植后的行走对妊娠率没有不利影响，因此，女性应在胚胎移植后立即恢复正常活动。
