Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM U1291, University of Toulouse, CNRS U5282, 31024 Toulouse, France.
Unit of Antibodies in Therapy and Pathology, Institut Pasteur, UMR1222 INSERM, 75015 Paris, France.
Science. 2021 Apr 9;372(6538). doi: 10.1126/science.abf2022.
Taniguchi (Research Articles, 17 July 2020, p. 269) claim that the cytokine interleukin-33 induces accumulation of tumor-associated macrophages expressing the immunoglobulin E receptor FcεRI. Although these findings hold great therapeutic promise, we provide evidence that the anti-FcεRI antibody used in this study is not specific for FcεRI on macrophages, which raises concerns about the validity of some of the conclusions.
谷口（研究文章，2020 年 7 月 17 日，第 269 页）声称细胞因子白细胞介素-33 诱导表达免疫球蛋白 E 受体 FcεRI 的肿瘤相关巨噬细胞的积累。尽管这些发现具有很大的治疗前景，但我们提供的证据表明，该研究中使用的抗 FcεRI 抗体并非特异性针对巨噬细胞上的 FcεRI，这引起了对一些结论有效性的关注。
