Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.
Department of Dermatology, Oregon Health & Science University, Portland, OR 97239, USA.
Science. 2021 Apr 9;372(6538). doi: 10.1126/science.abf3316.
Kamphuis argue that macrophages accumulated in the proximity of tumor-initiating cells do not express the high-affinity immunoglobulin E receptor FcεRIα. Although we cannot exclude the possibility of nonspecific binding of anti-FcεRIα antibody (clone MAR-1), we provide evidence that macrophages in squamous cell carcinomas express FcεRIα and that IL-33 induces FcεRIα expression in bone marrow cell-derived macrophages.
坎普希斯认为，聚集在肿瘤起始细胞附近的巨噬细胞不表达高亲和力免疫球蛋白 E 受体 FcεRIα。虽然我们不能排除抗 FcεRIα 抗体（克隆 MAR-1）非特异性结合的可能性，但我们提供的证据表明，在鳞状细胞癌中巨噬细胞表达 FcεRIα，并且 IL-33 诱导骨髓细胞衍生的巨噬细胞中 FcεRIα 的表达。
