Ma Da, Yao Zhi-Guang, Guo Yan-Ping, Wu Rui-Fa
Department of Pediatric General Surgery, Dongguan Eighth People's Hospital (Dongguan Children's Hospital), Dongguan, 523000, People's Republic of China.
Int J Gen Med. 2021 Mar 31;14:1173-1177. doi: 10.2147/IJGM.S301546. eCollection 2021.
Cryptorchidism is the most common congenital disability and is defined as the absence of one or both testicles in the scrotum during fetal development. In patients with cryptorchidism, lowered serum inhibin B levels suggest testicular dysfunction. The practical application of serum inhibin B levels in childhood remains controversial. The purpose of this study was to observe the post-operational changes of serum inhibin B levels in patients with cryptorchidism and provide evidence that serum inhibin B is a potential marker for the efficacy of testicular surgery.
A total of 83 male children with cryptorchidism were enrolled in this study. All the children had blood samples taken by venipuncture on the day of surgery. The serum inhibin B levels in the blood samples were measured using an ELISA kit. Paired -tests were used to assess differences between the groups.
The results show that, compared with the preoperative values, there was a statistically significant increase in serum inhibin B values one month after the operation in each group ( < 0.05). Compared with the one-month post-operation results, there were no significant changes six months after operation in each group (>0.05). However, serum inhibin B values decreased significantly in all groups at 12 months post-operation ( < 0.05), suggesting that serum inhibin B values are significantly correlated with age. Correlation analysis showed that serum inhibin B was negatively correlated with age from 6 to 36 months, and the correlation coefficient was -0.488.
Serum inhibin B can be used as a short-term evaluation index of cryptorchidism surgery rather than as a long-term indicator.
隐睾症是最常见的先天性残疾，定义为胎儿发育过程中阴囊内一个或两个睾丸缺失。在隐睾症患者中，血清抑制素B水平降低提示睾丸功能障碍。血清抑制素B水平在儿童期的实际应用仍存在争议。本研究的目的是观察隐睾症患者术后血清抑制素B水平的变化，并提供证据表明血清抑制素B是睾丸手术疗效的潜在标志物。
本研究共纳入83例隐睾症男童。所有儿童均在手术当天通过静脉穿刺采集血样。使用ELISA试剂盒检测血样中的血清抑制素B水平。采用配对检验评估组间差异。
结果显示，与术前值相比，每组术后1个月血清抑制素B值均有统计学意义的升高（<0.05）。与术后1个月结果相比，每组术后6个月无显著变化（>0.05）。然而，术后12个月时所有组的血清抑制素B值均显著下降（<0.05），提示血清抑制素B值与年龄显著相关。相关性分析显示，6至36个月时血清抑制素B与年龄呈负相关，相关系数为-0.488。
血清抑制素B可作为隐睾症手术的短期评估指标，而非长期指标。
