评论：尿新蝶呤，肌萎缩侧索硬化症神经炎症状态的一种新标志物。 - Suppr

Commentary: Urinary Neopterin, a New Marker of the Neuroinflammatory Status in Amyotrophic Lateral Sclerosis.

作者信息

Espíndola Gisele, Scheffer Débora da Luz, Latini Alexandra

机构信息

Laboratório de Bioenergética e Estresse Oxidativo, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil.

Ambulatório de Doenças Neuromusculares e Neurogenéticas Hospital Universitário Polydoro Ernani de São Thiago, Universidade Federal de Santa Catarina, Florianópolis, Brazil.

出版信息

Front Neurosci. 2021 Mar 23;15:645694. doi: 10.3389/fnins.2021.645694. eCollection 2021.

DOI:10.3389/fnins.2021.645694

PMID:33833664

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8021780/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5669/8021780/542822ee11c4/fnins-15-645694-g0001.jpg

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Commentary: Urinary Neopterin, a New Marker of the Neuroinflammatory Status in Amyotrophic Lateral Sclerosis.评论：尿新蝶呤，肌萎缩侧索硬化症神经炎症状态的一种新标志物。

Front Neurosci. 2021 Mar 23;15:645694. doi: 10.3389/fnins.2021.645694. eCollection 2021.

Amyotrophic lateral sclerosis an enigmatic disease with B-cellular and anti-retroviral immune responses.肌萎缩侧索硬化症：一种具有B细胞和抗逆转录病毒免疫反应的神秘疾病。

Eur J Med. 1993 Jun-Jul;2(6):327-32.

Daily urinary neopterin excretion as an immunological marker of disease activity in multiple sclerosis.每日尿新蝶呤排泄量作为多发性硬化症疾病活动的免疫标志物。

Brain. 1997 Jan;120 ( Pt 1):1-13. doi: 10.1093/brain/120.1.1.

The Role of Macrophages in Neuroinflammatory and Neurodegenerative Pathways of Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis: Pathogenetic Cellular Effectors and Potential Therapeutic Targets.巨噬细胞在阿尔茨海默病、肌萎缩侧索硬化症和多发性硬化症的神经炎症和神经退行性途径中的作用：发病机制的细胞效应物和潜在治疗靶点。

Int J Mol Sci. 2018 Mar 13;19(3):831. doi: 10.3390/ijms19030831.

Creatinine and C-reactive protein in amyotrophic lateral sclerosis, multiple sclerosis and Parkinson's disease.肌萎缩侧索硬化症、多发性硬化症和帕金森病中的肌酐和C反应蛋白。

Brain Commun. 2020 Sep 18;2(2):fcaa152. doi: 10.1093/braincomms/fcaa152. eCollection 2020.

Targeting Macrophage for the Treatment of Amyotrophic Lateral Sclerosis.靶向巨噬细胞治疗肌萎缩侧索硬化症

CNS Neurol Disord Drug Targets. 2019;18(5):366-371. doi: 10.2174/1871527318666190409103831.

Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases.细胞外 RNA 作为散发性肌萎缩侧索硬化症和其他神经退行性疾病的生物标志物。

Int J Mol Sci. 2019 Jun 27;20(13):3148. doi: 10.3390/ijms20133148.

Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis.单核细胞和中性粒细胞与肌萎缩侧索硬化症的临床特征相关。

Brain Commun. 2020 Feb 14;2(1):fcaa013. doi: 10.1093/braincomms/fcaa013. eCollection 2020.

Knee replacement surgery significantly elevates the urinary inflammatory biomarkers neopterin and 7,8-dihydroneopterin.膝关节置换手术会显著提高尿液中的炎症生物标志物新蝶呤和7,8-二氢新蝶呤的水平。

Clin Biochem. 2019 Jan;63:39-45. doi: 10.1016/j.clinbiochem.2018.11.002. Epub 2018 Nov 3.

Nutritional issues and supplements in amyotrophic lateral sclerosis and other neurodegenerative disorders.肌萎缩侧索硬化症及其他神经退行性疾病中的营养问题与补充剂

Curr Opin Clin Nutr Metab Care. 2002 Nov;5(6):631-43. doi: 10.1097/00075197-200211000-00005.

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Tetrahydrobiopterin: Beyond Its Traditional Role as a Cofactor.四氢生物蝶呤：超越其作为辅因子的传统作用。

Antioxidants (Basel). 2023 May 3;12(5):1037. doi: 10.3390/antiox12051037.

本文引用的文献

Urinary neopterin, a new marker of the neuroinflammatory status in amyotrophic lateral sclerosis.尿新蝶呤，肌萎缩侧索硬化症神经炎症状态的一种新标志物。

J Neurol. 2020 Dec;267(12):3609-3616. doi: 10.1007/s00415-020-10047-7. Epub 2020 Jul 8.

Peripheral proinflammatory Th1/Th17 immune cell shift is linked to disease severity in amyotrophic lateral sclerosis.周围炎症性 Th1/Th17 免疫细胞偏移与肌萎缩侧索硬化症的疾病严重程度相关。

Sci Rep. 2020 Apr 3;10(1):5941. doi: 10.1038/s41598-020-62756-8.

Phenotypic variability and its pathological basis in amyotrophic lateral sclerosis.肌萎缩侧索硬化症的表型变异性及其病理基础

Neuropathology. 2020 Feb;40(1):40-56. doi: 10.1111/neup.12606. Epub 2019 Dec 5.

Moderate running exercise prevents excessive immune system activation.适度的跑步锻炼可以防止免疫系统过度激活。

Physiol Behav. 2019 May 15;204:248-255. doi: 10.1016/j.physbeh.2019.02.023. Epub 2019 Feb 19.

Neopterin preconditioning prevents inflammasome activation in mammalian astrocytes.新型蝶呤预处理可防止哺乳类星形胶质细胞中的炎症小体激活。

Free Radic Biol Med. 2018 Feb 1;115:371-382. doi: 10.1016/j.freeradbiomed.2017.11.022. Epub 2017 Dec 2.

Fluid-Based Biomarkers for Amyotrophic Lateral Sclerosis.肌萎缩侧索硬化症的基于液体的生物标志物

Neurotherapeutics. 2017 Jan;14(1):119-134. doi: 10.1007/s13311-016-0503-x.

Neopterin acts as an endogenous cognitive enhancer.Neopterin 可作为内源性认知增强剂。

Brain Behav Immun. 2016 Aug;56:156-64. doi: 10.1016/j.bbi.2016.02.019. Epub 2016 Feb 23.

Neopterin as a potential cytoprotective brain molecule.新蝶呤作为一种潜在的细胞保护性脑分子。

J Psychiatr Res. 2015 Dec;71:134-9. doi: 10.1016/j.jpsychires.2015.10.003. Epub 2015 Oct 9.

Kuehne LK, Reiber H, Bechter K, Hagberg L, Fuchs D., Cerebrospinal fluid neopterin is brain-derived and not associated with blood-CSF barrier dysfunction in non-inflammatory affective and schizophrenic spectrum disorders. Journal of Psychiatric Research, Volume 47, Issue 10, October 2013, pages 1417-1422.库内 LK、赖贝尔 H、贝克特 K、哈格贝里 L、富克斯 D. 脑脊液新蝶呤源自大脑，与非炎性情感障碍和精神分裂症谱系障碍中的血脑脊液屏障功能障碍无关。《精神科研究杂志》，第47卷，第10期，2013年10月，第1417 - 1422页。

J Psychiatr Res. 2015 Apr;63:141-2. doi: 10.1016/j.jpsychires.2015.02.002. Epub 2015 Feb 25.

Cerebrospinal fluid neopterin is brain-derived and not associated with blood-CSF barrier dysfunction in non-inflammatory affective and schizophrenic spectrum disorders.脑脊液中新蝶呤是脑源性的，与非炎症性情感和精神分裂症谱系障碍中的血脑屏障功能障碍无关。

J Psychiatr Res. 2013 Oct;47(10):1417-22. doi: 10.1016/j.jpsychires.2013.05.027. Epub 2013 Jun 19.

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Commentary: Urinary Neopterin, a New Marker of the Neuroinflammatory Status in Amyotrophic Lateral Sclerosis.

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