Cassis L A, Lynch K R, Peach M J
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville.
Circ Res. 1988 Jun;62(6):1259-62. doi: 10.1161/01.res.62.6.1259.
The distribution of angiotensinogen messenger (mRNA) was determined in the rat aorta. Other investigators have demonstrated the presence of angiotensinogen mRNA in whole rat aorta; however, its precise location in the blood vessel wall has not been defined. When various layers of the vessel wall were separated by dissection or cell dispersion, angiotensinogen mRNA levels were greatest in the periaortic adipose tissue. Angiotensinogen mRNA was present in very small levels in the adventitia, with no detectable levels in the muscle layer. In addition to periaortic adipose tissue, angiotensinogen mRNA was also present in the interscapular brown fat pad of the rat. The high levels of angiotensinogen mRNA in periaortic brown adipose tissue suggests that angiotensin may be synthesized there and responses may exist in this tissue or adjacent sympathetic nerve terminals.
在大鼠主动脉中测定了血管紧张素原信使核糖核酸（mRNA）的分布。其他研究人员已证实在整个大鼠主动脉中存在血管紧张素原mRNA；然而，其在血管壁中的精确位置尚未明确。当通过解剖或细胞分散分离血管壁的各层时，血管紧张素原mRNA水平在主动脉周围脂肪组织中最高。血管紧张素原mRNA在外膜中的水平非常低，在肌肉层中未检测到。除主动脉周围脂肪组织外，血管紧张素原mRNA也存在于大鼠肩胛间棕色脂肪垫中。主动脉周围棕色脂肪组织中血管紧张素原mRNA的高水平表明血管紧张素可能在那里合成，并且该组织或相邻交感神经末梢可能存在反应。
