Zhang Lvming, Qiu Shi, Zhao Chunxia, Wang Peifu, Yu Shengyuan
Department of Neurology, Medical School of Chinese People's Liberation Army, Chinese People's Liberation Army General Hospital, Beijing, China.
Department of Neurology, Aerospace Center Hospital, Beijing, China.
Front Neurol. 2021 Mar 23;12:647092. doi: 10.3389/fneur.2021.647092. eCollection 2021.
It has been reported that autonomic nervous dysfunction is more prevalent in migraineurs. Heart rate variability (HRV) is a commonly used method to evaluate the cardiac autonomic nervous function modulation. However, HRV changes in migraine are still contradictory. The main objective of this study was to explore the potential HRV change patterns in episodic migraine (EM) and whether there were differences in HRV between EM ictal period and the interictal period. We conducted a cross-sectional study including 18 patients with EM and 18 age- and sex-matched controls. The characteristics of demographics, some lifestyle factors, and psychological conditions were assessed at baseline. HRVs including time-domain analysis and frequency-domain analysis were performed in all participants. HRV analyses in migraine were recorded not only in the interictal period but also in the ictal period. All the HRV parameters showed a decreased trend in migraine than controls. Time-domain parameters standard deviation of all NN intervals in 24 h (SDNN) and triangular index were significantly lower in the migraine ictal period than controls separately (SDNN, 56.94 ± 22.09 ± 7.76 vs. 135.78 ± 35.16, < 0.001; triangular index, 12.61 ± 3.20 vs. 22.11 ± 6.90, < 0.001). Frequency-domain parameter low-frequency power was also lower in the migraine ictal period than controls (351.28 ± 206.71 vs. 559.61 ± 281.24, = 0.02). SDNN was much lower in the migraine ictal period than migraine interictal period (56.94 ± 22.09 vs. 115.94 ± 46.88, < 0.001). HRV changes during migraine interictal period did not differ from the control group. The correlation analysis revealed a negative correlation between visual analog scale and HRV parameters in the migraine ictal period ( = 0.04). The present cross-sectional study indicates that HRV was significantly decreased in EM population especially during the migraine ictal period, which means unbalance of autonomic system in EM. Perhaps larger prospective cohort studies are wanted to validate these findings.
据报道，自主神经功能障碍在偏头痛患者中更为普遍。心率变异性（HRV）是评估心脏自主神经功能调节的常用方法。然而，偏头痛患者的HRV变化仍存在矛盾之处。本研究的主要目的是探讨发作性偏头痛（EM）潜在的HRV变化模式，以及EM发作期和发作间期的HRV是否存在差异。我们进行了一项横断面研究，纳入了18例EM患者和18例年龄及性别匹配的对照者。在基线时评估了人口统计学特征、一些生活方式因素和心理状况。对所有参与者进行了包括时域分析和频域分析在内的HRV检测。偏头痛患者的HRV分析不仅在发作间期进行，也在发作期进行。与对照组相比，偏头痛患者的所有HRV参数均呈下降趋势。时域参数24小时内所有正常心动周期（NN）间期的标准差（SDNN）和三角指数在偏头痛发作期分别显著低于对照组（SDNN，56.94±22.09±7.76对135.78±35.16，<0.001；三角指数，12.61±3.20对22.11±6.90，<0.001）。频域参数低频功率在偏头痛发作期也低于对照组（351.28±206.
