Ashkenazi A, Mushtaq A, Yang I, Oshinsky M L
Department of Neurology, Thomas Jefferson University, 11 South 11th Street, Suite 8130, Philadelphia, PA 19107, USA.
Cephalalgia. 2009 Oct;29(10):1042-8. doi: 10.1111/j.1468-2982.2008.01834.x. Epub 2009 Mar 12.
The aim of the study was to evaluate quantitatively ictal and interictal phonophobia in episodic migraine (EM). We included subjects with EM and age- and gender-matched controls. Sound stimuli were pure tones at frequencies of 1000, 4000 and 8000 Hz. Sound aversion thresholds (SATs) were determined as the minimal sound intensity perceived as unpleasant or painful. Migraineurs were examined both between and during attacks. We compared interictal SATs in migraineurs with those in controls. We also compared ictal and interictal SATs in migraineurs. Sixty migraineurs and 52 controls were included. Interictal mean SAT of migraineurs, averaged for the three frequencies, was significantly lower than that of controls [90.4 (0.8) dB vs. 105.9 (1.1) dB, respectively, P < 0.0001]. In migraineurs, mean ictal SAT, averaged for the three frequencies, was significantly lower than interictal SAT [76.0 (0.9) dB vs. 91.0 (0.8) dB, respectively, P < 0.0001]. Patients with EM exhibit increased sound aversion between attacks that is further augmented during an acute attack.
本研究的目的是定量评估发作性偏头痛（EM）发作期和发作间期的恐音症。我们纳入了患有EM的受试者以及年龄和性别匹配的对照组。声音刺激为频率为1000、4000和8000Hz的纯音。声音厌恶阈值（SATs）被确定为被感知为不愉快或疼痛的最小声音强度。偏头痛患者在发作期间和发作间期均接受检查。我们比较了偏头痛患者发作间期的SATs与对照组的SATs。我们还比较了偏头痛患者发作期和发作间期的SATs。共纳入60名偏头痛患者和52名对照组。偏头痛患者发作间期三个频率的平均SAT显著低于对照组[分别为90.4（0.8）dB和105.9（1.1）dB，P<0.0001]。在偏头痛患者中，三个频率的平均发作期SAT显著低于发作间期SAT[分别为76.0（0.9）dB和91.0（0.8）dB，P<0.0001]。发作性偏头痛患者在发作间期的声音厌恶增加，在急性发作期间进一步增强。
