广东汉族人群 STAT3 基因单核苷酸多态性 rs9891119 与 2 型糖尿病遗传易感性的关系。

Association between Single Nucleotide Polymorphism rs9891119 of STAT3 Gene and the Genetic Susceptibility to Type 2 Diabetes in Chinese Han Population from Guangdong.

机构信息

Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong Province 523808, China.

Shantou Hospital of Traditional Chinese Medicine, Shantou, Guangdong Province 515031, China.

出版信息

J Healthc Eng. 2021 Mar 24;2021:6657324. doi: 10.1155/2021/6657324. eCollection 2021.

DOI:10.1155/2021/6657324

PMID:33833859

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8012137/

Abstract

BACKGROUND

The aim of this study was to investigate the association between single nucleotide polymorphism (SNP) rs9891119 of the signal transducer and activator of the transcription 3 (STAT3) gene and genetic susceptibility to type 2 diabetes in Chinese Han population from the Guangdong province.

OBJECTIVE

The aim of the present study was to explore the relationship between single nucleotide polymorphism rs9891119 of STAT3 gene and type 2 diabetes mellitus (T2DM), which provides a basis for molecular genetic research on the pathogenesis of T2DM in Chinese Han population.

METHODS

In our case-control study, the SNP rs9891119 was picked out from the STAT3 gene and the SNP genotyping was performed by using the SNPscan kit in 1092 patients with type 2 diabetes as cases and 1092 normal persons as controls. The distributions of genotype and allele frequencies in two groups were analyzed by SPSS 20.0 software.

RESULTS

Our results showed that the alleles of A and C of rs9891119 of the STAT3 gene were 54.3 and 45.7% in patients with type 2 diabetes, while 55.5% and 44.5% in the normal persons, which have no statistical significance ( > 0.05). There were also no significant differences in AA, AC, and CC genotype frequencies between type 2 diabetes patients and normal persons. There were no significant differences in codominant, dominant, recessive, and overdominant genetic models of SNP rs9891119 before and after adjusting the covariant factors ( > 0.05).

CONCLUSIONS

Therefore, genetic susceptibility to type 2 diabetes may be not associated with SNP rs9891119 of the STAT3 gene in Chinese Han population from the Guangdong province.

摘要

背景

本研究旨在探讨广东汉族人群中信号转导子和转录激活子 3（STAT3）基因单核苷酸多态性（SNP）rs9891119 与 2 型糖尿病（T2DM）遗传易感性的关系。

目的

本研究旨在探讨 STAT3 基因单核苷酸多态性 rs9891119 与 2 型糖尿病的关系，为汉族人群 2 型糖尿病发病机制的分子遗传学研究提供依据。

方法

采用病例对照研究，选取 STAT3 基因中的 SNP rs9891119，应用 SNPscan 试剂盒对 1092 例 2 型糖尿病患者（病例组）和 1092 例正常对照者（对照组）进行 SNP 基因分型，采用 SPSS 20.0 软件分析两组基因型和等位基因频率分布。

结果

本研究结果显示，STAT3 基因 rs9891119 等位基因 A 和 C 在 2 型糖尿病患者中的频率分别为 54.3%和 45.7%，在正常人群中的频率分别为 55.5%和 44.5%，差异无统计学意义（>0.05）。2 型糖尿病患者与正常人群 AA、AC 和 CC 基因型频率差异亦无统计学意义。调整协变量后，SNP rs9891119 的共显性、显性、隐性和超显性遗传模型均无统计学差异（>0.05）。