一项队列研究中睡眠时长与 2 型糖尿病关联的荟萃分析。
A Meta-Analysis of a Cohort Study on the Association between Sleep Duration and Type 2 Diabetes Mellitus.
机构信息
Department of Hepatobiliary and Pancreas Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
School of Nursing, Yan'an University, Yan'an, Shaanxi 710061, China.
出版信息
J Diabetes Res. 2021 Mar 24;2021:8861038. doi: 10.1155/2021/8861038. eCollection 2021.
OBJECTIVE
To study the association between sleep duration and the incidence of type 2 diabetes mellitus (T2DM) and to provide a theoretical basis for the prevention of T2DM through a meta-analysis.
METHODS
PubMed, Web of Science, Scopus, Embase, Cochrane Library, ProQuest, CNKI, Wanfang, VIP, and SINOMED were searched from their inception until May 2020. All cohort studies on the relationship between sleep duration and T2DM in adults were included. According to the inclusion and exclusion criteria, two authors independently assessed the literature and extracted the data. Metaregression and publication bias were evaluated, and sensitivity and meta-analyses were conducted with RevMan 5.3.
RESULTS
A total of 17 studies were collected, involving 737002 adults. The incidence of T2DM was 4.73% in short sleep duration (SSD) ( ≤ 6 h), 4.39% in normal sleep duration (NSD) (6 h < < 9 h), and 4.99% in long sleep duration (LSD) ( ≥ 9 h). The meta-analysis demonstrated that SSD increased the risk of T2DM compared with NSD (RR = 1.22, 95% CI: 1.15-1.29, < 0.001), LSD increased the risk of T2DM compared with NSD (RR = 1.26, 95% CI: 1.15-1.39, < 0.001), and the risk of T2DM has no significant difference between SSD and LSD (RR = 0.97, 95% CI: 0.89-1.05, = 0.41). The sensitivity of each study was robust and the publication bias was weak.
CONCLUSION
SSD or LSD can increase the risk of T2DM.
目的
通过荟萃分析研究睡眠持续时间与 2 型糖尿病（T2DM）发病率之间的关系，为通过睡眠干预预防 T2DM 提供理论依据。
方法
计算机检索 PubMed、Web of Science、Scopus、Embase、Cochrane Library、ProQuest、中国知网、万方数据知识服务平台、维普网和中国生物医学文献服务系统，检索时限均从建库至 2020 年 5 月。收集关于成人睡眠持续时间与 T2DM 关系的队列研究，按照纳入与排除标准，由 2 位作者独立筛选文献并提取资料。采用 Meta 回归和发表偏倚评估，并采用 RevMan 5.3 软件进行敏感性分析和荟萃分析。
结果
共纳入 17 项研究，包含 737002 名成人。短睡眠持续时间（SSD）（≤6 h）、正常睡眠持续时间（NSD）（6 h ＜ ＜ 9 h）和长睡眠持续时间（LSD）（≥9 h）T2DM 的发生率分别为 4.73%、4.39%和 4.99%。Meta 分析结果显示，SSD 较 NSD 增加 T2DM 发病风险（RR=1.22，95% CI：1.151.29，＜0.001），LSD 较 NSD 增加 T2DM 发病风险（RR=1.26，95% CI：1.151.39，＜0.001），而 SSD 与 LSD 间 T2DM 发病风险差异无统计学意义（RR=0.97，95% CI：0.89~1.05， = 0.41）。各研究敏感性分析结果稳健，发表偏倚较小。
结论
SSD 或 LSD 均可增加 T2DM 发病风险。
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