Division of Public Health, Department of Social Medicine, Nihon University School of Medicine, Tokyo, Japan.
Department of Public Health and Epidemiology, Faculty of Medicine, Oita University, Oita, Japan.
Sleep Med Rev. 2018 Jun;39:25-36. doi: 10.1016/j.smrv.2017.06.011. Epub 2017 Jul 5.
We examined the dose-response relationship between long sleep duration and health outcomes including mortality and the incidence of diabetes mellitus, hypertension, cardiovascular diseases, stroke, coronary heart diseases, obesity, depression and dyslipidemia. We collected data from 5,134,036 participants from 137 prospective cohort studies. For the independent variable, we categorized participants at baseline as having long sleep duration or normal sleep duration. Risk ratios (RRs) for mortality and incident health conditions during follow-up were calculated through meta-analyses of adjusted data from individual studies. Meta-regression analyses were performed to investigate the association between each outcome and specific thresholds of long sleep. Long sleep was significantly associated with mortality (RR, 1.39; 95% CI, 1.31-1.47), incident diabetes mellitus (1.26, 1.11-1.43), cardiovascular disease (1.25, 1.14-1.37), stroke (1.46, 1.26-1.69), coronary heart disease (1.24, 1.13-1.37), and obesity (1.08, 1.02-1.15). Long sleep was not significantly related to incident hypertension (1.01, 0.95-1.07). Insufficient data were available for depression and dyslipidemia. Meta-regression analyses found statistically significant linear associations between longer sleep duration and increased mortality and incident cardiovascular disease. Future studies should address whether the relationship between long sleep and health outcomes is causal and modifiable.
我们研究了长睡眠时间与健康结果之间的剂量反应关系，包括死亡率以及糖尿病、高血压、心血管疾病、卒中等疾病的发病率。我们从 137 项前瞻性队列研究中收集了 5134036 名参与者的数据。对于自变量，我们将基线参与者分为长睡眠时间或正常睡眠时间。通过对个体研究中调整后数据的荟萃分析，计算了死亡率和随访期间新发健康状况的风险比（RR）。进行了荟萃回归分析，以调查每个结果与长睡眠特定阈值之间的关联。长睡眠与死亡率（RR，1.39；95%CI，1.31-1.47）、新发糖尿病（1.26，1.11-1.43）、心血管疾病（1.25，1.14-1.37）、卒中等疾病（1.46，1.26-1.69）、冠心病（1.24，1.13-1.37）和肥胖（1.08，1.02-1.15）显著相关。长睡眠与新发高血压（1.01，0.95-1.07）无显著相关性。关于抑郁和血脂异常的数据不足。荟萃回归分析发现，睡眠时间与死亡率和心血管疾病发病率增加之间存在统计学上显著的线性关联。未来的研究应探讨长睡眠与健康结果之间的关系是否具有因果关系和可改变性。
