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大网膜作为胰岛移植的部位。

The greater omentum as a site for pancreatic islet transplantation.

作者信息

Pellicciaro M, Vella I, Lanzoni G, Tisone G, Ricordi C

机构信息

Liver Transplant Center, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.

Diabetes Research Institute and Cell Transplant Center, University of Miami, Miami, FL, USA.

出版信息

CellR4 Repair Replace Regen Reprogram. 2017;5(3). Epub 2017 Jun 20.

PMID:33834082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8025931/
Abstract

The greater omentum is a highly vascularized anatomical structure in the peritoneal cavity. Its main components are connective, adipose and vascular cells, along with specialized immune cells. The omentum functions as a site for fat accumulation, it has adhesive properties to control traumatized and inflamed tissues, and a function in local hemostasis, immune responses, and revascularization. Other functions include the absorption of fluids, the phagocytosis of particulate matter, and foreign body reaction. The omentum is catalyzing significant interest for its potential as a site for pancreatic islet and cell transplantation. Our knowledge about this structure, its functions, and its potential as a site for transplantation is poised to grow in the coming years.

摘要

大网膜是腹腔内一个血管高度丰富的解剖结构。其主要成分是结缔组织细胞、脂肪细胞和血管细胞,以及特殊的免疫细胞。大网膜作为脂肪堆积的场所,具有黏附特性以控制受创伤和发炎的组织,并在局部止血、免疫反应和血管再生中发挥作用。其他功能包括液体吸收、颗粒物吞噬作用和异物反应。大网膜因其作为胰岛和细胞移植部位的潜力而引发了极大的关注。我们对这一结构、其功能以及作为移植部位的潜力的认识在未来几年有望不断增长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/8025931/ea0e11e99333/nihms-1057406-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/8025931/329ac516a99b/nihms-1057406-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/8025931/ca51c888ba83/nihms-1057406-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/8025931/45f4e29df8ee/nihms-1057406-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/8025931/b3cd211cdd8f/nihms-1057406-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/8025931/ea0e11e99333/nihms-1057406-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/8025931/329ac516a99b/nihms-1057406-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/8025931/ca51c888ba83/nihms-1057406-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/8025931/45f4e29df8ee/nihms-1057406-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/8025931/b3cd211cdd8f/nihms-1057406-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/8025931/ea0e11e99333/nihms-1057406-f0005.jpg

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Bioengineering of an Intraabdominal Endocrine Pancreas.腹腔内分泌胰腺的生物工程
N Engl J Med. 2017 May 11;376(19):1887-1889. doi: 10.1056/NEJMc1613959.
3
The mesentery: structure, function, and role in disease.肠系膜:结构、功能及其在疾病中的作用。
21 世纪胰岛移植的全球科学趋势:文献计量学和可视化分析。
Medicine (Baltimore). 2024 Apr 26;103(17):e37945. doi: 10.1097/MD.0000000000037945.
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From stem cells to pancreatic β-cells: strategies, applications, and potential treatments for diabetes.从干细胞到胰腺β细胞:糖尿病的治疗策略、应用及潜在疗法
Mol Cell Biochem. 2025 Jan;480(1):173-190. doi: 10.1007/s11010-024-04999-x. Epub 2024 Apr 20.
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Development of artificial bone graft via endochondral ossification (ECO) strategy for bone repair.通过软骨内成骨(ECO)策略开发用于骨修复的人工骨移植材料。
Mater Today Bio. 2023 Dec 3;23:100893. doi: 10.1016/j.mtbio.2023.100893. eCollection 2023 Dec.
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Long-term cultures of human pancreatic islets in self-assembling peptides hydrogels.人胰岛在自组装肽水凝胶中的长期培养
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