Van Bang Be Nguyen, Thanh Xuan Nguyen, Xuan Quang Dinh, Ba Loi Cao, Thai Ngoc Minh Nguyen, Nhu Lam Nguyen, Ngoc Anh Do, Thi Thu Hien Truong, Xuan Su Hoang, Tran-Anh Le
Department of Hamatology, Toxicology, Radiation, and Occupational Diseases, Military Hospital 103, Vietnam Military Medical University, Ha Dong, Ha Noi, Vietnam.
Department of Medical Education, Military Hospital 103, Vietnam Military Medical University, Ha Dong, Ha Noi, Vietnam.
Curr Med Mycol. 2020 Sep;6(3):42-49. doi: 10.18502/cmm.6.3.4664.
Burn patients are at a higher risk of infections caused by different organisms. This study aimed to address the prevalence, causative species, and factors related to fungal colonization or infection in patients with acute severe injuries admitted to the intensive care unit (ICU) of a burn hospital in northern Vietnam.
This prospective study was conducted on 400 patients in a burn ICU between 2017 and 2019. Clinical samples were weekly collected and screened for fungi, and relevant clinical information was obtained from medical records.
According to the results, 90% of the patients were colonized with fungi. Out of this group, 12.75% of the cases had invasive fungal infection (IFI). Eleven yeasts and six mold species were isolated from the patients, with the most common species being (45.56%) and (41.94%). Among the eleven species causing fungal wound infection (FWI), the most common agents were (66.7% of FWI patients) and (38.5%) species. Three species isolated from blood were (66.7%), (20.0%), and (14.3%). No factors were found to expose the patients to a higher risk of fungal colonization. However, hyperglycemia, prolonged ICU stay, and heavy species colonization were found to be independently predictive of IFI.
Burn patients are at the risk of fungal infection with species (especially ) and as the most frequently responsible agents. Continuous surveillance of fungi and appropriate management of pathophysiological consequences are essential to prevent fungal infection in burn patients.
烧伤患者感染由不同生物体引起的感染风险更高。本研究旨在探讨越南北方一家烧伤医院重症监护病房（ICU）收治的急性重伤患者中真菌定植或感染的患病率、致病菌种及相关因素。
本前瞻性研究于2017年至2019年在一家烧伤ICU的400例患者中进行。每周收集临床样本并进行真菌筛查，并从病历中获取相关临床信息。
根据结果，90%的患者有真菌定植。在这组患者中，12.75%的病例发生侵袭性真菌感染（IFI）。从患者中分离出11种酵母菌和6种霉菌，最常见的菌种是（45.56%）和（41.94%）。在导致真菌伤口感染（FWI）的11种菌种中，最常见的病原体是（FWI患者的66.7%）和（38.5%）菌种。从血液中分离出的3种菌种是（66.7%）、（20.0%）和（14.3%）。未发现使患者面临更高真菌定植风险的因素。然而，高血糖、ICU住院时间延长和大量菌种定植被发现是IFI的独立预测因素。
烧伤患者有感染真菌的风险，菌种（尤其是）和是最常见的致病因素。持续监测真菌并适当处理病理生理后果对于预防烧伤患者的真菌感染至关重要。
