Psychology Program, International University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
School of Advanced Studies, University of Tyumen, Tyumen, Russia.
Adv Exp Med Biol. 2021;1305:203-230. doi: 10.1007/978-981-33-6044-0_12.
The research of depression genetics has been occupied by historical candidate genes which were tested by candidate gene association studies. However, these studies were mostly not replicable. Thus, genetics of depression have remained elusive for a long time. As research moves from candidate gene association studies to GWAS, the hypothesis-free non-candidate gene association studies in genome-wide level, this trend will likely change. Despite the fact that the earlier GWAS of depression were not successful, the recent GWAS suggest robust findings for depression genetics. These altogether will catalyze a new wave of multidisciplinary research to pin down the neurobiology of depression.
抑郁症遗传学的研究一直以来都被历史候选基因所占据，这些基因通过候选基因关联研究进行了测试。然而，这些研究大多不可重复。因此，抑郁症的遗传学在很长一段时间内都难以捉摸。随着研究从候选基因关联研究转移到 GWAS（全基因组关联研究），即无假设的全基因组范围内的非候选基因关联研究，这种趋势可能会发生变化。尽管早期的抑郁症 GWAS 没有成功，但最近的 GWAS 为抑郁症遗传学提供了有力的发现。所有这些都将推动一波新的多学科研究，以确定抑郁症的神经生物学。
