揭示重度抑郁症的遗传结构。
Uncovering the Genetic Architecture of Major Depression.
机构信息
Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, NC, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
出版信息
Neuron. 2019 Apr 3;102(1):91-103. doi: 10.1016/j.neuron.2019.03.022.
Abstract
There have been several recent studies addressing the genetic architecture of depression. This review serves to take stock of what is known now about the genetics of depression, how it has increased our knowledge and understanding of its mechanisms, and how the information and knowledge can be leveraged to improve the care of people affected. We identify four priorities for how the field of MD genetics research may move forward in future years, namely by increasing the sample sizes available for genome-wide association studies (GWASs), greater inclusion of diverse ancestries and low-income countries, the closer integration of psychiatric genetics with electronic medical records, and the development of the neuroscience toolkit for polygenic disorders.
摘要
近年来已经有几项研究探讨了抑郁症的遗传结构。这篇综述旨在总结目前已知的关于抑郁症遗传学的知识，以及它如何增加我们对其机制的认识和理解，以及如何利用这些信息和知识来改善受影响人群的护理。我们确定了 MD 遗传学研究领域未来几年可能前进的四个优先事项，即增加全基因组关联研究 (GWAS) 的可用样本量，更大程度地纳入不同的祖先和低收入国家，更紧密地将精神遗传学与电子病历相结合，以及为多基因疾病开发神经科学工具包。
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