环芳烷类麦角甾烷型真菌天然产物 hirsutellone 家族的生物合成。
Biosynthesis of Cyclophane-Containing Hirsutellone Family of Fungal Natural Products.
机构信息
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, MOE-LSB and MOE-LSC, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
出版信息
J Am Chem Soc. 2021 Apr 21;143(15):5605-5609. doi: 10.1021/jacs.1c00098. Epub 2021 Apr 9.
Abstract
Hirsutellones are fungal natural products containing a macrocyclic cyclophane connected to a decahydrofluorene ring system. We have elucidated the biosynthetic pathway for pyrrocidine B () and GKK1032 A (). Two small hypothetical proteins, an oxidoreductase and a lipocalin-like protein, function cooperatively in the oxidative cyclization of the cyclophane, while an additional hypothetical protein in the pyrrocidine pathway catalyzes the specific cycloaddition to form the fused decahydrofluorene.
摘要
希鲁特酮类化合物是一类含有大环环丙烷连接到十氢芴环系统的真菌天然产物。我们阐明了吡咯西啶 B () 和 GKK1032 A () 的生物合成途径。两个小的假设蛋白，一种氧化还原酶和一种类脂蛋白，在环丙烷的氧化环化中协同作用，而吡咯西啶途径中的另一个假设蛋白则催化特定的环加成反应，形成融合的十氢芴。
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