Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Department of Life Sciences, Faculty of Science and Technology, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Cancer Causes Control. 2021 Jul;32(7):763-772. doi: 10.1007/s10552-021-01427-z. Epub 2021 Apr 9.
The aim of this study is to determine the demographic, pathological, and treatment-related factors that predict recurrence and survival in a Trinidadian cohort of breast cancer patients.
The inclusion criteria for this study were female, over 18 years, and with a primary breast cancer diagnosis confirmed by a biopsy report occurring between 2010 and 2015 at Sangre Grande Hospital, Trinidad. Univariate associations with 5-year recurrence-free survival and 5-year overall survival were calculated using the Kaplan-Meier method for categorical variables and Cox Proportional Hazards for continuous variables. A multivariate model for prediction of recurrence and survival was determined using Cox regression.
For the period 2010-2015, 202 records were abstracted. Five-year overall survival and recurrence-free survival rates were found to be 74.3% and 56.4%, respectively. Median times from first suspicious finding to date of biopsy report, date of surgery, and date of chemotherapy were 63 days, 125 days, and 189 days, respectively. In the univariate analysis, age (p = 0.038), stage (p < 0.001), recurrence (p = 0.035), surgery (p = 0.016), ER (p < 0.001) status, PR status (p < 0.001), and subtype (p < 0.001) were significantly associated with survival. Additionally, stage (p = 0.004), N score (p = 0.002), ER (p = 0.028) status, PR (p = 0.018) status, and subtype (p = 0.025) were significantly associated with recurrence. In the Cox multivariate model, Stage 4 was a significant predictor of survival (HR 6.77, 95% CI [0.09-2.49], p = 0.047) and N3 score was a significant predictor of recurrence (HR 4.47, 95% CI [1.29-15.54], p = 0.018).
This study reports a 5-year breast cancer survival rate of 74.3%, and a recurrence-free survival rate of 56.4% in Trinidad for the period 2010-2015.
本研究旨在确定特立尼达队列中乳腺癌患者的人口统计学、病理学和治疗相关因素，这些因素可预测复发和生存。
本研究的纳入标准为女性、年龄超过 18 岁，以及在 2010 年至 2015 年间在特立尼达 Sangre Grande 医院接受活检报告确诊的原发性乳腺癌。使用 Kaplan-Meier 方法计算 5 年无复发生存率和 5 年总生存率的单变量关联，并用 Cox 比例风险模型计算连续变量的单变量关联。使用 Cox 回归确定用于预测复发和生存的多变量模型。
在 2010-2015 年期间，共提取了 202 份记录。发现 5 年总生存率和无复发生存率分别为 74.3%和 56.4%。从首次可疑发现到活检报告日期、手术日期和化疗日期的中位数时间分别为 63 天、125 天和 189 天。在单变量分析中，年龄（p=0.038）、分期（p<0.001）、复发（p=0.035）、手术（p=0.016）、ER（p<0.001）状态、PR 状态（p<0.001）和亚型（p<0.001）与生存显著相关。此外，分期（p=0.004）、N 评分（p=0.002）、ER（p=0.028）状态、PR（p=0.018）状态和亚型（p=0.025）与复发显著相关。在 Cox 多变量模型中，第 4 期是生存的显著预测因素（HR 6.77，95%CI[0.09-2.49]，p=0.047），N3 评分是复发的显著预测因素（HR 4.47，95%CI[1.29-15.54]，p=0.018）。
本研究报告了 2010-2015 年期间特立尼达乳腺癌的 5 年生存率为 74.3%，无复发生存率为 56.4%。
