功能环形 RNA 数据库资源。

Database Resources for Functional Circular RNAs.

机构信息

Department of Bioinformatics, The State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China.

出版信息

Methods Mol Biol. 2021;2284:457-466. doi: 10.1007/978-1-0716-1307-8_24.

DOI:10.1007/978-1-0716-1307-8_24

PMID:33835457

Abstract

Circular RNA (or circRNA) is a type of single-stranded covalently closed circular RNA molecule and play important roles in diverse biological pathways. A comprehensive functionally annotated circRNA database will help to understand the circRNAs and their functions. CircFunBase is such a web-accessible database that aims to provide a high-quality functional circRNA resource including experimentally validated and computationally predicted functions. CircFunBase provides visualized circRNA-miRNA interaction networks. In addition, a genome browser is provided to visualize the genome context of circRNA. In this chapter, we illustrate examples of searching for circRNA and getting detailed information of circRNA. Moreover, other circRNA related databases are outlined.

摘要

环状 RNA（circRNA）是一种单链共价封闭环状 RNA 分子，在多种生物途径中发挥重要作用。一个全面的功能注释环状 RNA 数据库将有助于理解环状 RNA 及其功能。CircFunBase 就是这样一个可访问的数据库，旨在提供高质量的功能性环状 RNA 资源，包括实验验证和计算预测的功能。CircFunBase 提供可视化的环状 RNA-miRNA 相互作用网络。此外，还提供了基因组浏览器，用于可视化环状 RNA 的基因组背景。在本章中，我们举例说明了如何搜索环状 RNA 并获取环状 RNA 的详细信息。此外，还概述了其他与环状 RNA 相关的数据库。