CircFunBase：一个用于功能环状 RNA 的数据库。
CircFunBase: a database for functional circular RNAs.
机构信息
Department of Bioinformatics, the State Key Laboratory of Plant Physiology and Biochemistry, Institute of Plant Science, College of Life Sciences, Zhejiang University, Hangzhou, China.
The State Key Laboratory of Crop Biology, Shandong Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, China.
出版信息
Database (Oxford). 2019 Jan 1;2019:baz003. doi: 10.1093/database/baz003.
Increasing evidence reveals that circular RNAs (circRNAs) are widespread in eukaryotes and play important roles in diverse biological processes. However, a comprehensive functionally annotated circRNA database is still lacking. CircFunBase is a web-accessible database that aims to provide a high-quality functional circRNA resource including experimentally validated and computationally predicted functions. The current version of CircFunBase documents more than 7000 manually curated functional circRNA entries, mainly including Homo sapiens, Mus musculus etc. CircFunBase provides visualized circRNA-miRNA interaction networks. In addition, a genome browser is provided to visualize the genome context of circRNAs. As a biological information platform for circRNAs, CircFunBase will contribute for circRNA studies and bridge the gap between circRNAs and their functions.
越来越多的证据表明，环状 RNA（circRNAs）广泛存在于真核生物中，并在多种生物学过程中发挥重要作用。然而，一个全面的功能注释环状 RNA 数据库仍然缺乏。CircFunBase 是一个可访问的网络数据库，旨在提供一个高质量的功能环状 RNA 资源，包括实验验证和计算预测的功能。CircFunBase 的当前版本记录了超过 7000 个经过人工精心整理的功能环状 RNA 条目，主要包括智人、小家鼠等。CircFunBase 提供可视化的环状 RNA-微小 RNA 相互作用网络。此外，还提供了一个基因组浏览器，用于可视化环状 RNA 的基因组背景。作为环状 RNA 的生物信息平台，CircFunBase 将有助于环状 RNA 的研究，并弥合环状 RNA 与其功能之间的差距。
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