In Vivo X-ray Triggered Catalysis of H Generation for Cancer Synergistic Gas Radiotherapy.

To date, hydrogen (H ) therapy has received widespread attention. However, X-ray triggered sustainable H -producing materials with controlled release for cancer treatment have not been reported. Herein, an X-ray triggered sustainable in situ H producing platform, Au NR-TiO @ZnS:Cu,Co-A(Au-TiO @ZnS), composed of Au-amorphous TiO nano-dumbbell-shaped heterostructure coated with long afterglow particles, was developed for cancer synergistic H -radiotherapy. The mechanism of H production was verified by theoretical calculations and in vitro experiments. Changes in the apoptosis pathway caused by the synergistic effect of H and radiotherapy were reported. Guided by its excellent photoacoustic imaging capabilities, mice with orthotopic liver cancer achieved excellent therapeutic effects and low inflammatory side effects, suggesting that Au-TiO @ZnS has promising application potential for cancer treatment and prognosis.