Liang Xinqiang, Kurboniyon Mekhrdod S, Zou Yuanhan, Luo Kezong, Fang Shuhong, Xia Pengle, Ning Shufang, Zhang Litu, Wang Chen
Department of Research, Guangxi Cancer Molecular Medicine Engineering Research Center, Guangxi Medical University Cancer Hospital, Nanning 530021, China.
National Academy of Sciences of Tajikistan, Dushanbe 734000, Tajikistan.
Pharmaceutics. 2023 Oct 10;15(10):2443. doi: 10.3390/pharmaceutics15102443.
Traditional treatment methods for tumors are inefficient and have severe side effects. At present, new therapeutic methods such as phototherapy, chemodynamic therapy, and gasodynamic therapy have been innovatively developed. High concentrations of hydrogen sulfide (HS) gas exhibit cancer-suppressive effects. Herein, a Prussian blue-loaded tetra-sulfide modified dendritic mesoporous organosilica (PB@DMOS) was rationally constructed with glutathione (GSH)-triggered/photothermal-enhanced HS signaling molecule release properties for gas therapy. The as-synthesized nanoplatform confined PB nanoparticles in the mesoporous structure of organosilica silica due to electrostatic adsorption. In the case of a GSH overexpressed tumor microenvironment, HS gas was controllably released. And the temperature increases due to the photothermal effects of PB nanoparticles, further enhancing HS release. At the same time, PB nanoparticles with excellent hydrogen peroxide catalytic performance also amplified the efficiency of tumor therapy. Thus, a collective nanoplatform with gas therapy/photothermal therapy/catalytic therapy functionalities shows potential promise in terms of efficient tumor therapy.
肿瘤的传统治疗方法效率低下且副作用严重。目前，光疗、化学动力学疗法和气体动力学疗法等新的治疗方法已得到创新性发展。高浓度硫化氢（HS）气体具有抗癌作用。在此，合理构建了一种负载普鲁士蓝的四硫化物修饰树枝状介孔有机硅（PB@DMOS），其具有谷胱甘肽（GSH）触发/光热增强的HS信号分子释放特性用于气体治疗。由于静电吸附作用，所合成的纳米平台将PB纳米颗粒限制在有机硅的介孔结构中。在GSH过表达的肿瘤微环境中，HS气体可控释放。并且由于PB纳米颗粒的光热效应导致温度升高，进一步增强了HS释放。同时，具有优异过氧化氢催化性能的PB纳米颗粒也提高了肿瘤治疗的效率。因此，一种具有气体治疗/光热治疗/催化治疗功能的集体纳米平台在高效肿瘤治疗方面显示出潜在的前景。
