Dermatology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Pathology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Transpl Infect Dis. 2021 Aug;23(4):e13613. doi: 10.1111/tid.13613. Epub 2021 Apr 27.
Dermatophytes are common keratinophilic fungi responsible for superficial skin infections. Deep dermatophytosis is a rare form of invasive skin infection described in immunocompromised patients. We report the case of a 65-year-old man with a history of an orthotopic liver transplant for hepatocarcinoma 6 months earlier, who presented with small painless erythematous papules in lower limbs, some of which were umbilicated. Skin biopsy showed an intense non-necrotizing granulomatous reaction in the dermis around fungal structures. Trichophyton rubrum was identified as the causal agent through culture and internal transcribed spacer sequencing.
皮肤癣菌是常见的亲角质真菌,可引起皮肤浅表感染。深部皮肤癣菌病是一种罕见的侵袭性皮肤感染形式,见于免疫功能低下的患者。我们报告了 1 例 65 岁男性病例,6 个月前因肝癌行原位肝移植,他下肢出现小而无痛的红斑丘疹,部分呈脐状。皮肤活检显示真皮内围绕真菌结构存在强烈的非坏死性肉芽肿反应。通过培养和内部转录间隔区测序鉴定出红色毛癣菌为致病因子。