Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
Mycopathologia. 2013 Dec;176(5-6):457-62. doi: 10.1007/s11046-013-9696-2. Epub 2013 Aug 28.
Dermatophytes are the main pathogen of superficial skin fungal infections. On rare occasions, they can cause deep and extensive infections, especially in immunocompromised hosts. We reported a 48-year-old patient with liver cirrhosis and chronic renal failure who developed an extensive deep dermatophytosis with possible hematogenous dissemination. Skin histopathology showed extensive involvement of hair follicles and dermis by fungal elements. The pathogen was cultured from both skin biopsy specimen and central venous line. It was identified as Trichophyton rubrum by morphology and further conformed by sequencing of internal transcribed spacers of ribosomal DNA. The patient died quickly before the identification was available.
皮肤癣菌是引起浅部皮肤真菌感染的主要病原体。在极少数情况下，它们可引起深部广泛感染，尤其在免疫功能低下的宿主中。我们报告了 1 例 48 岁的肝硬化和慢性肾衰竭患者，其发生了广泛的深部皮肤癣菌病，可能存在血行播散。皮肤组织病理学显示真菌成分广泛累及毛囊和真皮。从皮肤活检标本和中心静脉导管均培养出病原菌。其形态学鉴定为红色毛癣菌，核糖体 DNA 内部转录间隔区测序进一步证实了这一结果。在鉴定结果出来之前，患者迅速死亡。
