Mehta J B, Dutt A K, Harvill L, Henry W
Department of Internal Medicine, Quillen-Dishner College of Medicine, East Tennessee State University, Johnson City 37601.
Chest. 1988 Jul;94(1):138-41. doi: 10.1378/chest.94.1.138.
Contact investigation activities of the Tennessee Department of Health and Environment (TDHE) Tuberculosis (TB) Control Program from 1979 to 1985 were reviewed. Out of 32,722 identified contacts, 6,030 (20.1 percent) were infected (positive purified protein derivative [PPD]). Only 2,731 (45 percent) of the infected contacts were started on preventive therapy. Both the absolute number and the relative percentage of infected contacts starting on INH prevention therapy have gradually declined over the years. While 569 (67 percent) of the infected contacts were started on preventive treatment in 1979, only 296 (37.5 percent) received isoniazid (INH) preventive therapy in 1985. Although an increasing percentage of those starting preventive therapy completed the prescribed course, the enthusiasm for recommending preventive therapy has declined for the infected individuals above the age of 15. More enthusiasm and efforts are needed from physicians in initiating and maintaining INH preventive therapy to accomplish tuberculosis eradication.
对田纳西州卫生与环境部（TDHE）结核病控制项目1979年至1985年的接触者调查活动进行了回顾。在32722名已识别的接触者中，6030人（20.1%）受到感染（纯化蛋白衍生物[PPD]检测呈阳性）。只有2731名（45%）受感染的接触者开始接受预防性治疗。多年来，开始接受异烟肼预防治疗的受感染接触者的绝对数量和相对百分比都在逐渐下降。1979年有569名（67%）受感染的接触者开始接受预防性治疗，而1985年只有296名（37.5%）接受了异烟肼（INH）预防性治疗。尽管开始接受预防性治疗的人中完成规定疗程的比例在增加，但对于15岁以上受感染个体推荐预防性治疗的热情有所下降。为实现结核病根除，医生在启动和维持异烟肼预防性治疗方面需要付出更多热情和努力。
