Department of Anesthesia, The First Affiliated Hospital of Nanchang University, No.17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People's Republic of China.
Department of Orthodontics, The Affiliated Stomatological Hospital of Nanchang University, No.49 Fuzhou Road, Nanchang, Jiangxi, 330008, People's Republic of China.
BMC Anesthesiol. 2021 Apr 10;21(1):109. doi: 10.1186/s12871-021-01329-2.
Hypertonic saline solution has been frequently utilized in clinical practice. However, due to the nonphysiological osmolality, hypertonic saline infusion usually induces local vascular pain. We conducted this study to evaluate the effect of lidocaine coinfusion for alleviating vascular pain induced by hypertonic saline.
One hundred and six patients undergoing hypertonic saline volume preloading prior to spinal anesthesia were randomly allocated to two groups of 53 each. Group L received a 1 mg/kg lidocaine bolus followed by infusion of 2 mg/kg/h through the same IV line during hypertonic saline infusion; Group C received a bolus and infusion of normal saline of equivalent volume. Visual analogue scale (VAS) scores of vascular pain were recorded every 4 min.
The vascular pain severity in Group L was significantly lower than that in Group C for each time slot (P < 0.05). The overall incidence of vascular pain during hypertonic saline infusion in Group L was 48.0%, which was significantly lower than the incidence (79.6%) in Group C (P < 0.05).
Lidocaine coinfusion could effectively alleviate vascular pain induced by hypertonic saline infusion.
Chinese Clinical Trial Registry, number: ChiCTR1900023753 . Registered on 10 June 2019.
高渗盐水溶液在临床实践中经常被使用。然而，由于其非生理渗透压，高渗盐水输注通常会引起局部血管疼痛。我们进行这项研究旨在评估利多卡因输注减轻高渗盐水引起的血管疼痛的效果。
106 名在脊髓麻醉前接受高渗盐水容量预负荷的患者被随机分为两组，每组 53 人。L 组在输注高渗盐水期间通过同一静脉输液线给予 1mg/kg 利多卡因推注，然后以 2mg/kg/h 的速度输注；C 组给予等量的生理盐水推注和输注。每 4 分钟记录一次血管疼痛的视觉模拟评分（VAS）。
L 组在每个时间点的血管疼痛严重程度均显著低于 C 组（P<0.05）。L 组在输注高渗盐水期间血管疼痛的总发生率为 48.0%，明显低于 C 组的发生率（79.6%）（P<0.05）。
利多卡因输注可有效减轻高渗盐水输注引起的血管疼痛。
中国临床试验注册中心，编号：ChiCTR1900023753。于 2019 年 6 月 10 日注册。
