Stem Cell Transplant Program, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio.
Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Transplant Cell Ther. 2021 Apr;27(4):286-291. doi: 10.1016/j.jtct.2020.11.008.
For cord blood transplantation (CBT), appropriate patient and conditioning regimen selection is necessary to achieve long-term disease-free survival. This review aims to provide comprehensive guidelines on these issues using evidence from the literature and experience at dedicated CBT centers. Topics include patient and disease characteristics that make CBT a good or poor choice and a review of outcomes in commonly used conditioning regimens in CBT. This is accompanied with recommendations on regimen intensity based on disease, organ function, and patient performance status and age. In addition, the use of antithymocyte globulin in CBT is discussed, as is the choice of conditioning in aplastic anemia patients who have access to acceptable CB units.
对于脐带血移植（CBT），需要选择合适的患者和预处理方案，以实现长期无病生存。本综述旨在使用来自文献和专门的 CBT 中心经验的证据，提供关于这些问题的综合指南。讨论的主题包括使 CBT 成为良好或不良选择的患者和疾病特征，以及对 CBT 中常用预处理方案的结果进行回顾。同时，根据疾病、器官功能、患者表现状态和年龄，给出了基于方案强度的建议。此外，还讨论了 CBT 中使用抗胸腺细胞球蛋白的问题，以及在能够获得可接受的 CB 单位的再生障碍性贫血患者中选择预处理方案的问题。
