University of British Columbia, Vancouver, British Columbia, Canada.
Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota.
Transplant Cell Ther. 2021 Apr;27(4):352.e1-352.e5. doi: 10.1016/j.jtct.2021.01.009. Epub 2021 Jan 15.
The incidence and risk factors for severe adverse events (SAEs) in related donors (RD) of hematopoietic cell transplants is unknown. The Related Donor Safe study is a prospective observational cohort of 1680 RDs and represents an opportunity to examine characteristics of SAEs in RDs. In this cohort, we found that SAEs were reported in a total 12 (0.71%) RDs. Of these, 5 SAEs occurred in bone marrow donors (5/404, 1.24%), and 7 (7/1276, 0.55%) were in donors of peripheral blood stem cells. All of the SAEs were considered to be related (definite, probable, or possible) to the donation process. There were no donor fatalities. Of the 12 RDs who experienced an SAE, 10 were either overweight or obese. Five of the 12 RDs had predonation medical conditions that would have resulted in either possible or definite ineligibility for donation were they being assessed as unrelated donors. These SAE data will be useful in the counseling of prospective RDs before planned donation and may be helpful in identifying donors who should be considered medically unsuitable for donation.
造血细胞移植相关供者（RD）发生严重不良事件（SAE）的发生率和风险因素尚不清楚。相关供者安全研究是一项对 1680 名 RD 进行的前瞻性观察性队列研究，为研究 RD 中 SAE 的特征提供了机会。在该队列中，我们发现共有 12 名（0.71%）RD 报告发生 SAE。其中，5 例 SAE 发生在骨髓供者（5/404，1.24%），7 例（7/1276，0.55%）发生在外周血造血干细胞供者。所有 SAE 均被认为与捐献过程相关（明确、可能或很可能）。无供者死亡。在发生 SAE 的 12 名 RD 中，有 10 名超重或肥胖。如果这些 RD 被评估为无关供者，那么在进行评估时，他们中的 5 人存在可能或明确的不适合捐献的预捐前医疗状况。这些 SAE 数据将有助于在计划捐献前对潜在 RD 进行咨询，并可能有助于确定应被认为不适合捐献的供者。
