Medical Sciences Division, University of Oxford, Oxford, UK.
Department of Gynaecology Oncology, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK.
BMJ Case Rep. 2021 Apr 9;14(4):e241461. doi: 10.1136/bcr-2020-241461.
Ovarian tumours harbouring foci of anaplastic carcinoma are extremely rare. With just a handful of cases reported in the literature, understanding of the disease and optimal management remains limited. A 38-year-old woman was referred to the gynaeoncologists with a multiloculated complex ovarian mass. High-grade mucinous ovarian carcinoma with mural nodules of anaplastic carcinoma was found on biopsy. Furthermore, an umbilical Sister Mary Joseph nodule signalled advanced metastatic disease. The patient underwent primary debulking surgery and was referred for adjuvant chemotherapy. High-quality radiological and surgical images are included to illustrate the approach taken to preoperative diagnosis and described surgical technique. Our case demonstrates the aggressive and rapidly progressive nature of mucinous ovarian carcinoma bearing anaplastic components. Sharing experience of such cases generates awareness and highlights the need for early detection and thorough investigations to guide subsequent management.
卵巢肿瘤中存在间变癌病灶极为罕见。文献中仅报道了少数几例病例,因此对这种疾病的认识和最佳治疗方法仍有限。一名 38 岁女性因多房性复杂卵巢肿块被转介给妇科肿瘤学家。活检发现高级别黏液性卵巢癌伴间变癌壁结节。此外,脐部 Sister Mary Joseph 结节提示存在晚期转移性疾病。患者接受了初次肿瘤细胞减灭术,并被转介接受辅助化疗。本病例包括高质量的影像学和手术图像,以说明术前诊断所采用的方法和描述的手术技术。我们的病例表明,具有间变成分的黏液性卵巢癌具有侵袭性和快速进展的性质。分享此类病例的经验可以提高认识,并强调需要早期发现和彻底检查以指导后续管理。