Department of Radiation Oncology, Medical Faculty of Saglik, Bilimleri University, Dr. Abdurrahman Yurtarslan Oncology Research and Training Hospital, Ankara, Turkey.
Department of Radiation Oncology, Medical Faculty of Cumhuriyet University, Sivas, Turkey.
Eur Arch Otorhinolaryngol. 2021 Jun;278(6):1945-1955. doi: 10.1007/s00405-021-06798-2. Epub 2021 Apr 9.
This study aimed to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune-inflammation index (SII) with the clinical and pathological parameters of 118 laryngeal cancer patients, as well as their effects on the survival of the disease.
For the calculation of SII, PLR, and NLR, hemogram tests were conducted before treatment. Receiver-operating characteristic (ROC) analysis was used to calculate the cut-off value of SII, NLR, and PLR for overall survival (OS) and disease-free survival (DFS).
A statistically significant relationship was found between SII and lymphovascular invasion and between NLR and local recurrence, and lymphovascular invasion. In a univariate analysis, SII (p < 0.001) and NLR (p = 0.001) for OS and SII (p < 0.001), PLR (p = 0.043), and NLR (p < 0.001) for DFS were detected as prognostic factors. In a multivariate analysis for OS, SII (HR = 10.54, 95% CI 1.28-86.77; p = 0.029) and extracapsular extension (HR = 3.08, 95% CI 1.15-8.21; p = 0.024) were identified as independent prognostic factors. In a multivariate analysis for DFS, only an extracapsular extension presence (HR = 3.32, 95% CI 1.37-8.08; p = 0.008) was detected as an independent prognostic factor.
In laryngeal cancer, high SII values were determined as poor independent prognostic factors for OS. High SII, NLR, and PRL have been identified as poor prognostic factors in DFS. A correlation was found between NLR and local recurrence, and lymphovascular invasion and between SII with lymphovascular invasion positivity.
本研究旨在探讨中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和全身免疫炎症指数（SII）与 118 例喉癌患者临床病理参数的关系及其对疾病生存的影响。
在治疗前进行血液常规检查以计算 SII、PLR 和 NLR。采用受试者工作特征（ROC）分析计算 SII、NLR 和 PLR 对总生存期（OS）和无病生存期（DFS）的截断值。
SII 与脉管侵犯之间以及 NLR 与局部复发和脉管侵犯之间存在统计学显著关系。单因素分析中，SII（p<0.001）和 NLR（p=0.001）对 OS 和 SII（p<0.001）、PLR（p=0.043）和 NLR（p<0.001）对 DFS 均被检测为预后因素。OS 的多因素分析中，SII（HR=10.54，95%CI 1.28-86.77；p=0.029）和囊外扩展（HR=3.08，95%CI 1.15-8.21；p=0.024）被确定为独立的预后因素。DFS 的多因素分析中，仅发现囊外扩展（HR=3.32，95%CI 1.37-8.08；p=0.008）为独立的预后因素。
在喉癌中，高 SII 值被确定为 OS 的不良独立预后因素。高 SII、NLR 和 PLR 被确定为 DFS 的不良预后因素。NLR 与局部复发和脉管侵犯之间以及 SII 与脉管侵犯阳性之间存在相关性。
