Department of Biochemistry, Microbiology & Immunology, Wayne State University School of Medicine, Detroit, MI, United States.
Department of Biochemistry, Microbiology & Immunology, Wayne State University School of Medicine, Detroit, MI, United States.
Adv Virus Res. 2020;108:337-392. doi: 10.1016/bs.aivir.2020.09.003. Epub 2020 Oct 7.
The human betaherpesviruses, human cytomegalovirus (HCMV; species Human betaherpesvirus 5) and human herpesviruses 6A, 6B, and 7 (HHV-6A, -6B, and -7; species Human betaherpesviruses 6A, 6B, and 7) are highly prevalent and can cause severe disease in immune-compromised and immune-naive populations in well- and under-developed communities. Herpesvirus virion assembly is an intricate process that requires viral orchestration of host systems. In this review, we describe recent advances in some of the many cellular events relevant to assembly and egress of betaherpesvirus virions. These include modifications of host metabolic, immune, and autophagic/recycling systems. In addition, we discuss unique aspects of betaherpesvirus virion structure, virion assembly, and the cellular pathways employed during virion egress.
人类β疱疹病毒、人类巨细胞病毒（HCMV；β疱疹病毒 5 种）和人类疱疹病毒 6A、6B 和 7（HHV-6A、6B 和 7；β疱疹病毒 6A、6B 和 7 种）广泛流行，可在发达和欠发达社区的免疫功能低下和免疫功能正常人群中引起严重疾病。疱疹病毒病毒体的组装是一个复杂的过程，需要病毒对宿主系统进行协调。在这篇综述中，我们描述了与β疱疹病毒病毒体组装和出芽相关的许多细胞事件中的最新进展。这些进展包括宿主代谢、免疫和自噬/回收系统的改变。此外，我们还讨论了β疱疹病毒病毒体结构、病毒体组装以及病毒体出芽过程中使用的细胞途径的独特方面。
